Please cite this article as follows: Szatmari P, Maziade M, Zwaigenbaum L, Mérette C, Roy M-A, Joober R, Palmour R. 2007. Informative Phenotypes for Genetic Studies of Psychiatric Disorders. Am J Med Genet Part B 144B:581–588.
Informative phenotypes for genetic studies of psychiatric disorders†
Article first published online: 11 JAN 2007
Copyright © 2007 Wiley-Liss, Inc.
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Volume 144B, Issue 5, pages 581–588, 5 July 2007
How to Cite
Szatmari, P., Maziade, M., Zwaigenbaum, L., Mérette, C., Roy, M.-A., Joober, R. and Palmour, R. (2007), Informative phenotypes for genetic studies of psychiatric disorders. Am. J. Med. Genet., 144B: 581–588. doi: 10.1002/ajmg.b.30426
- Issue published online: 21 JUN 2007
- Article first published online: 11 JAN 2007
- Manuscript Accepted: 1 AUG 2006
- Manuscript Received: 7 JUL 2005
- mood disorder
Despite its initial promise, there has been both progress and some set backs in genetic studies of the major psychiatric disorders of childhood and adulthood. Finding true susceptibility genes may be delayed because the most genetically informative phenotypes are not being used on a regular basis in linkage analysis and association studies. It is highly likely that using alternative phenotypes instead of DSM diagnostic categories will lead more rapid success in the search for these susceptibility genes. The objective of this paper is to describe the different types of informative phenotypes that can be employed in psychiatric genetic studies, to clarify their uses, to identify several methodologic issues the design and conduct of linkage and association studies that use alternative phenotypes and finally to suggest possible solutions to those difficulties. This is a conceptual review with a focus on methodological issues that may arise in psychiatric genetics and examples are taken from the literature on autism, schizophrenia, bipolar disorder, and alcoholism. © 2007 Wiley-Liss, Inc.