Association analysis of GABA receptor subunit genes on 5q33 with heroin dependence in a Chinese male population

Authors

  • E.W. Loh,

    1. Division of Psychiatry and Drug Abuse Research, National Health Research Institutes at Taipei City Psychiatric Center, Sinyi District, Taipei City, Taiwan
    2. Department of Psychiatry, Mackay Memorial Hospital, Taipei, Taiwan
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  • N.L.S. Tang,

    1. Department of Chemical Pathology, Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
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  • D.T.S. Lee,

    1. Department of Psychiatry, Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
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  • S.I. Liu,

    1. Department of Psychiatry, Mackay Memorial Hospital, Taipei, Taiwan
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  • Alfreda Stadlin

    Corresponding author
    1. Department of Anatomy, Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
    2. School of Medical Science, Griffith University, Southport, Queensland, Australia
    • School of Medical Science, Griffith University, Gold Coast Campus, Gold Coast Mail Centre PMB50, Southport, Qld 9726, Australia.
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  • Please cite this article as follows: Loh EW, Tang NLS, Lee DTS, Liu SI, Stadlin A. 2007. Association Analysis of GABA Receptor Subunit Genes on 5q33 With Heroin Dependence in a Chinese Male Population. Am J Med Genet Part B 144B:439–443.

Abstract

GABAA receptor subunit genes clustered on 5q33 play a role in the development of alcoholism and methamphetamine use disorder without psychosis. The present study explored the possible contribution of the same subunit genes to the development of heroin dependence. Single nucleotide polymorphisms (SNPs) of the GABAA receptor subunits GABRB2, GABRA6, GABRA1, and GABRG2 were examined in 178 male Han Chinese heroin-dependent and 170 male control subjects. A significant difference in allele frequency for the SNP rs211014 in the GABAAγ2 receptor subunit gene between cases and controls was identified (P = 0.015). A possible mechanism for the involvement of the GABA receptor subunit genes on 5q33 in the development of heroin dependence is discussed. © 2007 Wiley-Liss, Inc.

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