Please cite this article as follows: Cervilla JA, Rivera M, Molina E, Torres-González F, Bellón JA, Moreno B, de Dios Luna J, Lorente JA, de Diego-Otero Y, King M, Nazareth I, Gutierrez B. 2006. The 5-HTTLPR s/s Genotype at the Serotonin Transporter Gene (SLC6A4) Increases the Risk for Depression in a Large Cohort of Primary Care Attendees: The PREDICT-Gene Study. Am J Med Genet Part B 141B:912–917.
The 5-HTTLPR s/s genotype at the serotonin transporter gene (SLC6A4) increases the risk for depression in a large cohort of primary care attendees: The PREDICT-gene study†
Article first published online: 24 OCT 2006
Copyright © 2006 Wiley-Liss, Inc.
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Volume 141B, Issue 8, pages 912–917, 5 December 2006
How to Cite
Cervilla, J. A., Rivera, M., Molina, E., Torres-González, F., Bellón, J. A., Moreno, B., de Dios Luna, J., Lorente, J. A., de Diego-Otero, Y., King, M., Nazareth, I. and Gutiérrez, B. (2006), The 5-HTTLPR s/s genotype at the serotonin transporter gene (SLC6A4) increases the risk for depression in a large cohort of primary care attendees: The PREDICT-gene study. Am. J. Med. Genet., 141B: 912–917. doi: 10.1002/ajmg.b.30455
Miguel Xavier, Igor Slav, Heidi-Ingrid Maaros, Jan Neelman, Francisco Torres-Gonzalez, Irwin Nazareth and Michael King.
- Issue published online: 22 NOV 2006
- Article first published online: 24 OCT 2006
- Manuscript Accepted: 20 SEP 2006
- Manuscript Received: 14 JUL 2006
- Vth Framework Program of the European Commission
- University of Granada. Grant Number: 30.PP.00.5000
- Ministry of Education and Science (Spain). Grant Number: SAF-2004-01310
- serotonin transporter;
- generalized anxiety
Previous reports and meta-analyses have yielded inconclusive results as to whether the s/s genotype at the 5-HTTLPR serotonin transporter polymorphism confers increased risk for depression. We tested the association between s/s genotype and depression in a large cohort (n = 737) of Spanish primary care consecutive attendees participating in a European study on predictors for depression in primary care (PREDICT study). Participants were administered the Composite International Diagnostic Interview (CIDI) depression subscale allowing diagnoses using ICD-10 criteria for depressive episodes. Participants were genotyped to establish 5HTTLPR genotype. Both univariable and multivariable associations between the s/s genotype and depression were tested twice using two different depressive outcomes (ICD-10 depressive episode and ICD-10 severe depressive episode). We found an association between the s/s genotype and both depressive outcomes that was independent of age, sex, family history of psychological problems among first degree relatives and presence of comorbid generalized anxiety disorder. When comparing s/s homozygous versus the rest, the adjusted odds ratio for any ICD-10 depressive episode and for severe ICD-10 depressive episode were 1.50 (95% CI: 1.0–2.2; P = 0.045) and 1.79 (95% CI: 1.1–2.8; P = 0.016), respectively. The association was significantly stronger with increasing severity of depression (χ2 for linear association=6.1; P = 0.013) suggesting a dose-dependent relationship. Our results are consistent with previous reports suggesting a small but independent effect by the s/s 5-HTTLPR genotype increasing the risk for depression. © 2006 Wiley-Liss, Inc.