Please cite this article as follows: Syed Z, Dudbridge F, Kent L. 2007. An Investigation of the Neurotrophic Factor Genes GDNF, NGF, and NT3 in Susceptibility to ADHD. Am J Med Genet Part B 144B:375–378.
Brief Research Communication
An investigation of the neurotrophic factor genes GDNF, NGF, and NT3 in susceptibility to ADHD†
Article first published online: 27 DEC 2006
Copyright © 2006 Wiley-Liss, Inc.
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Volume 144B, Issue 3, pages 375–378, 5 April 2007
How to Cite
Syed, Z., Dudbridge, F. and Kent, L. (2007), An investigation of the neurotrophic factor genes GDNF, NGF, and NT3 in susceptibility to ADHD. Am. J. Med. Genet., 144B: 375–378. doi: 10.1002/ajmg.b.30459
- Issue published online: 27 MAR 2007
- Article first published online: 27 DEC 2006
- Manuscript Accepted: 21 SEP 2006
- Manuscript Received: 28 JUN 2006
- The Wellcome Trust
- attention deficit hyperactivity disorder;
- association study;
- neurotrophic factor;
Attention deficit hyperactivity disorder (ADHD) is a common, highly heritable, neurodevelopmental disorder with onset in early childhood. Genes involved in neuronal development and growth are, thus, important etiological candidates and neurotrophic factors have been hypothesized to play a role in the pathogenesis of ADHD. Glial derived neurotrophic factor (GDNF), nerve growth factor (NGF (beta subunit)), and neurotrophic factor 3 (NT3) are members of the neurotrophin family and are involved in the survival, differentiation, and maintenance of neuronal cells. We have examined 10 coding and intronic single nucleotide polymorphisms (SNPs) across GDNF, NGF, and NT3 in a family-based association sample of 120 DSM-IV ADHD probands and their biological parents, as well as a case-control analysis with 120 sex-matched controls. Borderline significant overtransmission of the C allele of a non-synonymous C/T SNP (rs6330) in NGF which codes an alanine/valine change was found in the family-based sample (Chi-square = 3.69, odds ratio (OR) = 1.65, P = 0.05). Although this SNP is located in the 5′ pro-NGF sequence and not the mature NGF protein, it may affect intracellular processing and secretion of NGF. © 2006 Wiley-Liss, Inc.