Please cite this article as follows: Chen C-M, Chen I-C, Chang K-H, Chen Y-C, Lyu R-K, Liu Y-T, Hu F-J, Chao C-Y, Lee-Chen G-J, Wu Y-R. 2007. Nuclear Receptor NR4A2 IVS6 +18insG and Brain Derived Neurotrophic Factor (BDNF) V66M Polymorphisms and Risk of Taiwanese Parkinson's Disease. Am J Med Genet Part B 144B:458–462.
Nuclear receptor NR4A2 IVS6 +18insG and brain derived neurotrophic factor (BDNF) V66M polymorphisms and risk of Taiwanese parkinson's disease†
Article first published online: 10 APR 2007
Copyright © 2007 Wiley-Liss, Inc.
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Volume 144B, Issue 4, pages 458–462, 5 June 2007
How to Cite
Chen, C.-M., Chen, I.-C., Chang, K.-H., Chen, Y.-C., Lyu, R.-K., Liu, Y.-T., Hu, F.-J., Chao, C.-Y., Lee-Chen, G.-J. and Wu, Y.-R. (2007), Nuclear receptor NR4A2 IVS6 +18insG and brain derived neurotrophic factor (BDNF) V66M polymorphisms and risk of Taiwanese parkinson's disease. Am. J. Med. Genet., 144B: 458–462. doi: 10.1002/ajmg.b.30476
- Issue published online: 24 MAY 2007
- Article first published online: 10 APR 2007
- Manuscript Accepted: 30 OCT 2006
- Manuscript Received: 20 AUG 2006
- Chang Gung Memorial Hospital, Taipei, Taiwan. Grant Numbers: CMRPG 33142, CMRPG 33065
- National Science Council. Grant Numbers: NSC-94-3112-B-003-001, NSC-94-2314-B-182A-059
- NR4A2 IVS6 +18insG;
- BDNF V66M;
- Parkinson's disease;
- age at onset;
- disease association
Both of environmental and genetic factors confer vulnerability to Parkinson's disease (PD). NR4A2 (Nurr1), a member of the steroid/thyroid hormone nuclear receptor superfamily, is essential for the neurogenesis and differentiation of dopaminergic neurons in the midbrain. Brain derived neurotrophic factor (BDNF) deficiency may play a role in the pathogenesis of PD, as the surviving dopaminergic nigrostriatal neurons have reduced levels of BDNF. This study examines whether BDNF V66M (c.196 G A) or NR4A2 IVS6 +18insG polymorphism is associated with the risk of Taiwanese PD and the age of onset using a case-control study. The genotype or allele frequency distribution of both BDNF V66M and NR4A2 IVS6 +18insG polymorphisms was not significantly different between the cases and the controls. Neither BDNF nor NR4A2 polymorphism influences PD onset age. Notably, after stratification by sex, female individuals carrying the NR4A2 2G/2G genotype demonstrated a trend toward significant decrease in risk of developing PD (OR = 0.49, 95% CI = 0.25–0.96, P = 0.039). These results suggest that the NR4A2 IVS6 +18insG polymorphism may play a minor role in PD susceptibility among Taiwanese women. © 2007 Wiley-Liss, Inc.