Association analysis of COMT polymorphisms and schizophrenia in a Chinese Han population: A case-control study

Authors

  • Rui Yu,

    1. Department of Biochemistry and Genetics, and Department of Cell Biology, Institute of Cell Biology, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China
    2. Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    3. Graduate School of the Chinese Academy of Sciences, Shanghai, China
    4. The National Education Base for Basic Medical Sciences, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China
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  • Xian-Ning Zhang,

    Corresponding author
    1. Department of Biochemistry and Genetics, and Department of Cell Biology, Institute of Cell Biology, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China
    2. The National Education Base for Basic Medical Sciences, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China
    • Department of Biochemistry and Genetics, and Department of Cell Biology, Institute of Cell Biology, Zhejiang University School of Medicine, Hangzhou 310058, Zhejiang Province, China.
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  • Xiao-Xiao Huang,

    1. Department of Biochemistry and Genetics, and Department of Cell Biology, Institute of Cell Biology, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China
    2. The National Education Base for Basic Medical Sciences, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China
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  • Shi-Ping Ding,

    1. Department of Biochemistry and Genetics, and Department of Cell Biology, Institute of Cell Biology, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China
    2. The National Education Base for Basic Medical Sciences, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China
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  • Ji-Cheng Li

    1. Department of Biochemistry and Genetics, and Department of Cell Biology, Institute of Cell Biology, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China
    2. The National Education Base for Basic Medical Sciences, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China
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  • Please cite this article as follows: Yu R, Zhang X-N, Huang X-X, Ding S-P, Li J-C. 2007. Association Analysis of COMT Polymorphisms and Schizophrenia in a Chinese Han Population: A Case-Control Study. Am J Med Genet Part B 144B:570–573.

Abstract

Schizophrenia is a common disease with complex mode of inheritance; great efforts have been made to identify the susceptible genes. Catechol-O-methyltransferase (COMT) gene has long been considered as a candidate gene mainly because of two reasons: First, it encodes a key dopamine catabolic enzyme. Second, it maps to the velocardiofacial syndrome (VCFS) region of chromosome 22q11, which is associated with schizophrenia predisposition. Numerous case-control and family-based studies have been conducted, majority of them focused on a functional Val/Met polymorphism (rs4680). Unfortunately, these studies have produced conflicting results. In a previous report, Shifman et al. found a three-marker haplotype (rs737865–rs4680–rs165599) that showed significant association with schizophrenia. In this study, we try to replicate their findings in Chinese Han population and failed to find any associations. © 2007 Wiley-Liss, Inc.

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