Suping Wu and Weihua Yue contributed equally to this work.
Article first published online: 10 APR 2007
Copyright © 2007 Wiley-Liss, Inc.
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Volume 144B, Issue 4, pages 492–495, 5 June 2007
How to Cite
Wu, S., Yue, W., Jia, M., Ruan, Y., Lu, T., Gong, X., Shuang, M., Liu, J., Yang, X. and Zhang, D. (2007), Association of the neuropilin-2 (NRP2) gene polymorphisms with autism in Chinese Han population. Am. J. Med. Genet., 144B: 492–495. doi: 10.1002/ajmg.b.30495
Please cite this article as follows: Wu S, Yue W, Jia M, Ruan Y, Lu T, Gong X, Shuang M, Liu J, Yang X, Zhang D. 2007. Association of the Neuropilin-2 (NRP2) Gene Polymorphisms With Autism in Chinese Han Population. Am J Med Genet Part B 144B:492–495.
- Issue published online: 24 MAY 2007
- Article first published online: 10 APR 2007
- Manuscript Accepted: 19 DEC 2006
- Manuscript Received: 29 AUG 2006
- National Natural Science Foundation of China. Grant Numbers: 30270495, 30530290, 30400149
- Beijing Biomedical R & D Innovation Program. Grant Number: H010210180112
- National Key Project. Grant Number: 2002BA711A07-06
- single nucleotide polymorphism (SNP);
- transmission disequilibrium test (TDT);
Autism is a pervasive neurodevelopmental disorder, with a significant role of genetic factors in its development. The neuropilin-2 (NRP2) gene is localized to 2q34, an autism susceptibility locus. NRP2 has been demonstrated to both guide axons and to control neuronal migration in the central nervous system. It has been reported that NRP2 may be required in vivo for sorting migrating cortical and striatal interneurons to their correct destination. We examine the association between the NRP2 gene and autism using a cohort of 169 Chinese Han family trios. Four single nucleotide polymorphisms (SNPs) were genotyped by the polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP) analyses. The transmission disequilibrium tests (TDT) of SNPs and haplotype association were carried out using the TDTPHASE program. We found significant genetic association between autism and two of the SNPs of the NRP2 gene (rs849578: P = 0.017, rs849563: P = 0.027), as well as specific haplotypes, especially those formed by rs849563. Furthermore, haplotypes constructed with all markers showed significant excess transmission in both global and individual haplotype analyses (P = 0.004 and 0.017, respectively). The polymorphisms in the NRP2 gene are associated with autism, implying that the NRP2 gene may render individuals to be predisposed to autism. © 2007 Wiley-Liss, Inc.