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Mitochondrial DNA haplogroups and age at onset of schizophrenia

Authors

  • Chiara Magri,

    1. Division of Biology and Genetics, Department of Biomedical Sciences and Biotechnology, Brescia University School of Medicine, Brescia, Italy
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  • Rita Gardella,

    1. Division of Biology and Genetics, Department of Biomedical Sciences and Biotechnology, Brescia University School of Medicine, Brescia, Italy
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  • Stefano Davide Barlati,

    1. Department of Mental Health, Brescia Spedali Civili, Brescia, Italy
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  • Paolo Valsecchi,

    1. Department of Mental Health, Brescia Spedali Civili, Brescia, Italy
    2. University Psychiatric Unit, Brescia University School of Medicine, Brescia, Italy
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  • Emilio Sacchetti,

    1. Department of Mental Health, Brescia Spedali Civili, Brescia, Italy
    2. University Psychiatric Unit, Brescia University School of Medicine, Brescia, Italy
    3. Chair of Psychiatry, Brescia University School of Medicine, Brescia, Italy
    4. Centre on Behavioural and Neurodegenerative Disorders, Brescia University and EULO, Brescia, Italy
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  • Sergio Barlati

    Corresponding author
    1. Division of Biology and Genetics, Department of Biomedical Sciences and Biotechnology, Brescia University School of Medicine, Brescia, Italy
    2. Centre on Behavioural and Neurodegenerative Disorders, Brescia University and EULO, Brescia, Italy
    • Division of Biology and Genetics, Department of Biomedical Sciences and Biotechnology, Brescia University School of Medicine, Viale Europa 11, 25123 Brescia, Italy.
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  • Please cite this article as follows: Magri C, Gardella R, Barlati SD, Valsecchi P, Sacchetti E, Barlati S. 2007. Mitochondrial DNA Haplogroups and Age at Onset of Schizophrenia. Am J Med Genet Part B 144B:496–501.

Abstract

A number of studies support a possible link between mitochondrial dysfunction and schizophrenia. To test the hypothesis of a direct contribution of mitochondrial DNA (mt-DNA) in susceptibility to DSM-IV-TR-schizophrenia, we looked for differences in the frequency distribution of the major European haplogroups (hgs) in 142 patients and 190 controls both of Italian origin. A subgroup of patients (N = 37) and healthy counterparts (N = 41) was also analyzed for possible differences in the relative amount of mt-DNA versus nuclear-DNA in blood cells. Patients and controls were comparable for hg frequency distribution and the relative levels of mt-DNA even after stratification by gender and schizophrenia subtype. However, patients harboring the hg J-T showed an anticipated onset of the disorder. These results indicate that the J-T hg of mt-DNA may have a modulator effect on deeper determinants of schizophrenia. © 2007 Wiley-Liss, Inc.

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