Please cite this article as follows: Hamilton G, Proitsi P, Jehu L, Morgan A, Williams J, O'Donovan MC, Owen MJ, Powell JF, Lovestone S. 2007. Candidate Gene Association Study of Insulin Signaling Genes and Alzheimer's Disease: Evidence for SOS2, PCK1, and PPARγ as Susceptibility Loci. Am J Med Genet Part B 144B:508–516.
Candidate gene association study of insulin signaling genes and Alzheimer's disease: Evidence for SOS2, PCK1, and PPARγ as susceptibility loci†
Article first published online: 17 APR 2007
Copyright © 2007 Wiley-Liss, Inc.
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Volume 144B, Issue 4, pages 508–516, 5 June 2007
How to Cite
Hamilton, G., Proitsi, P., Jehu, L., Morgan, A., Williams, J., O'Donovan, M. C., Owen, M. J., Powell, J. F. and Lovestone, S. (2007), Candidate gene association study of insulin signaling genes and Alzheimer's disease: Evidence for SOS2, PCK1, and PPARγ as susceptibility loci. Am. J. Med. Genet., 144B: 508–516. doi: 10.1002/ajmg.b.30503
- Issue published online: 24 MAY 2007
- Article first published online: 17 APR 2007
- Manuscript Accepted: 3 JAN 2007
- Manuscript Received: 8 SEP 2006
- Alzheimer's Research Trust
- Medical Research Council
- Wellcome Trust
- late-onset Alzheimer's disease;
- type II diabetes
Epidemiological evidence supports the existence of a possible link between type II diabetes mellitus (T2DM) and late-onset Alzheimer's disease (LOAD). Polymorphisms from candidate genes for T2DM were genotyped in a two-stage approach to identify novel risk factors for LOAD. One hundred fifty-two polymorphisms were initially genotyped in a case:control cohort: nine SNPs showed individual association with disease status under at least one genetic model, while an additional two SNPs showed a haplotype association. In a replication study, we confirmed significant association of SNPs within three genes—PPARγ, SOS2, and PCK1—with Alzheimer's disease. In particular, our data suggest that the effect of variants within these genes might be influenced by gender. © 2007 Wiley-Liss, Inc.