Please cite this article as follows: Tortorella A, Monteleone P, Martiadis V, Perris F, Maj M. 2007. The 3111T/C Polymorphism of the CLOCK Gene Confers a Predisposition to a Lifetime Lower Body Weight in Patients With Anorexia Nervosa and Bulimia Nervosa: A Preliminary Study. Am J Med Genet Part B 144B:992–995.
The 3111T/C polymorphism of the CLOCK gene confers a predisposition to a lifetime lower body weight in patients with anorexia nervosa and bulimia nervosa: A preliminary study†
Article first published online: 21 MAY 2007
Copyright © 2007 Wiley-Liss, Inc.
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Volume 144B, Issue 8, pages 992–995, 5 December 2007
How to Cite
Tortorella, A., Monteleone, P., Martiadis, V., Perris, F. and Maj, M. (2007), The 3111T/C polymorphism of the CLOCK gene confers a predisposition to a lifetime lower body weight in patients with anorexia nervosa and bulimia nervosa: A preliminary study. Am. J. Med. Genet., 144B: 992–995. doi: 10.1002/ajmg.b.30508
- Issue published online: 13 NOV 2007
- Article first published online: 21 MAY 2007
- Manuscript Accepted: 10 JAN 2007
- Manuscript Received: 11 OCT 2006
- anorexia nervosa;
- bulimia nervosa;
- gene polymorphisms;
- CLOCK gene
Feeding is subjected to circadian regulation; therefore, changes in the components of the endogenous oscillator regulating circadian rhythms may be involved in disordered rhythmicity of eating behavior as it occurs in anorexia nervosa (AN) and bulimia nervosa (BN). We investigated whether the 3111T/C polymorphism of the CLOCK gene, which is part of the endogenous oscillator system, was associated to AN and/or BN. A total of 241 women, including 90 healthy controls, 60 patients with AN and 91 patients with BN, participated into the study. The frequencies of 3111T/C genotypes and alleles did not significantly differ among the groups. In both the AN and BN group, subjects carrying one copy of the C allele had a lifetime body weight significantly lower than those carrying the T/T genotype. These findings, although preliminary, suggest that the 3111T/C polymorphism of the CLOCK gene does not play a major role in the genetic vulnerability to AN and BN, but it seems to predispose eating disorders (EDs) patients to a more severe lifetime body weight loss. © 2007 Wiley-Liss, Inc.