Please cite this article as follows: Iga J-I, Ueno S-I, Yamauchi K, Numata S, Tayoshi-Shibuya S, Kinouchi S, Nakataki M, Song H, Hokoishi K, Tanabe H, Sano A, Ohmori T. 2007. The Val66Met Polymorphism of the Brain-Derived Neurotrophic Factor Gene Is Associated With Psychotic Feature and Suicidal Behavior in Japanese Major Depressive Patients. Am J Med Genet Part B 144B:1003–1006.
The Val66Met polymorphism of the brain-derived neurotrophic factor gene is associated with psychotic feature and suicidal behavior in Japanese major depressive patients†
Article first published online: 17 MAY 2007
Copyright © 2007 Wiley-Liss, Inc.
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Volume 144B, Issue 8, pages 1003–1006, 5 December 2007
How to Cite
Iga, J.-I., Ueno, S.-I., Yamauchi, K., Numata, S., Tayoshi-Shibuya, S., Kinouchi, S., Nakataki, M., Song, H., Hokoishi, K., Tanabe, H., Sano, A. and Ohmori, T. (2007), The Val66Met polymorphism of the brain-derived neurotrophic factor gene is associated with psychotic feature and suicidal behavior in Japanese major depressive patients. Am. J. Med. Genet., 144B: 1003–1006. doi: 10.1002/ajmg.b.30520
- Issue published online: 13 NOV 2007
- Article first published online: 17 MAY 2007
- Manuscript Accepted: 8 FEB 2007
- Manuscript Received: 2 OCT 2006
- Health and Labor Science Research Grant from the
- Japanese Ministry of Health, Labor and Welfare. Grant Number: kokoro H16-002
- Japanese Ministry of Education, Culture, Sports, Science and Technology. Grant Number: 16390325
- Scientific Research from the 21st Century COE Program
- Human Nutritional Science on Stress Control, Tokushima, Japan
- major depressive disorder;
- age of onset;
- family history
Recent researches have suggested that brain-derived neurotrophic factor (BDNF) may be implicated in the pathophysiology of mood disorder. This study examined the association between the BDNF Val66Met polymorphism and major depressive disorder (MDD) in a Japanese population. We genotyped the BDNF Val66Met polymorphism in 154 major depressive patients and 154 age- and sex-matched control subjects. The genotypic distributions and allele frequencies were similar among the patients and control subjects. When the relationships of the polymorphism with several clinical variables (i.e., age, sex, age of onset, number of episode, presence of psychotic features, suicidal behavior, and family history) were examined, the dose of Met allele had significant effects on psychotic feature and suicidal behavior and family history. These results suggest that the BDNF Val66Met polymorphism is not related to the development of MDD but related to clinical features of MDD in a Japanese population. © 2007 Wiley-Liss, Inc.