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The effect of genetic variation of the serotonin 1B receptor gene on impulsive aggressive behavior and suicide

Authors

  • Hana Zouk,

    1. McGill Group for Suicide Studies, Douglas Hospital Research Center, McGill University, Montreal, Canada
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  • Alexander McGirr,

    1. McGill Group for Suicide Studies, Douglas Hospital Research Center, McGill University, Montreal, Canada
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  • Véronique Lebel,

    1. McGill Group for Suicide Studies, Douglas Hospital Research Center, McGill University, Montreal, Canada
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  • Chawky Benkelfat,

    1. McGill Group for Suicide Studies, Douglas Hospital Research Center, McGill University, Montreal, Canada
    2. McGill University, Department of Psychiatry, Montreal, Canada
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  • Guy Rouleau,

    1. McGill Group for Suicide Studies, Douglas Hospital Research Center, McGill University, Montreal, Canada
    2. Faculty of Medicine, University of Montreal, CHUM Research Center, Notre-Dame Hospital, Montreal, Canada
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  • Gustavo Turecki

    Corresponding author
    1. McGill Group for Suicide Studies, Douglas Hospital Research Center, McGill University, Montreal, Canada
    • McGill Group for Suicide Studies, Douglas Hospital Research Center, McGill University, 6875 LaSalle Blvd., Montreal QC H4H 1R3, Canada.
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  • Please cite this article as follows: Zouk H, McGirr A, Lebel V, Benkelfat C, Rouleau G, Turecki G. 2007. The Effect of Genetic Variation of the Serotonin 1B Receptor Gene on Impulsive Aggressive Behavior and Suicide. Am J Med Genet Part B 144B:996–1002.

Abstract

Impulsive–aggressive behaviors (IABs) are regarded as possible suicide intermediate phenotypes, mediating the relationship between genes and suicide outcome. In this study, we aimed to investigate the putative relationship between genetic variation at the 5-HT1B receptor gene, which in animal models is involved in impulse-aggression control, IABs, and suicide risk. We investigated the relationship of variation at five 5-HT1B loci and IAB measures in a sample of 696 subjects, including 338 individuals who died by suicide and 358 normal epidemiological controls. We found that variation at the 5-HT1B promoter A-161T locus had a significant effect on levels of IABs, as measured by the Buss–Durkee Hostility Inventory (BDHI). Suicides also differed from controls in distribution of variants at this locus. The A-161T locus, which seems to impact 5-HT1B transcription, could play a role in suicide predisposition by means of mediating impulsive–aggressive behaviors. © 2007 Wiley-Liss, Inc.

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