Please cite this article as follows: Xuei X, Flury-Wetherill L, Bierut L, Dick D, Nurnberger J, Foroud T, Edenberg HJ. 2007. The Opioid System in Alcohol and Drug Dependence: Family-Based Association Study. Am J Med Genet Part B 144B:877–884.
The opioid system in alcohol and drug dependence: Family-based association study†
Article first published online: 14 MAY 2007
Copyright © 2007 Wiley-Liss, Inc.
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Volume 144B, Issue 7, pages 877–884, 5 October 2007
How to Cite
Xuei, X., Flury-Wetherill, L., Bierut, L., Dick, D., Nurnberger, J., Foroud, T. and Edenberg, H. J. (2007), The opioid system in alcohol and drug dependence: Family-based association study. Am. J. Med. Genet., 144B: 877–884. doi: 10.1002/ajmg.b.30531
- Issue published online: 14 SEP 2007
- Article first published online: 14 MAY 2007
- Manuscript Accepted: 23 FEB 2007
- Manuscript Received: 23 OCT 2006
- µ- and δ-opioid receptors;
Opioid receptors and their endogenous peptide ligands play important roles in neurotransmission and neuromodulation in response to addictive drugs such as heroin, cocaine, and alcohol. In an earlier study, we reported that variation in the genes encoding the κ-opioid receptor (OPRK1) and its peptide ligand (PDYN) were associated with the risk for alcoholism. We continued our investigation of the role of the opioid system in alcohol dependence by analyzing the genes encoding the µ- and δ-opioid receptors and their peptide ligands. We analyzed 18 OPRM1 SNPs, 18 OPRD1 SNPs, 7 PENK SNPs, and 7 POMC SNPs in a sample of 1923 European Americans from 219 multiplex alcohol dependent families. Employing a family-based test of association, we found no evidence that these four genes were significantly associated with alcohol dependence. We also did not find association between these genes and illicit drug dependence. Secondary analyses employing the narrower phenotype of opioid dependence (83 affected individuals) demonstrated association with SNPs in PENK and POMC, but not in OPRM1 or OPRD1. Haplotype analyses provided further support for the association of PENK and POMC with opioid dependence. Therefore, our data provide no support for the idea that variations in OPRM1, OPRD1, PENK and POMC are associated with alcohol dependence or general illicit drug dependence, but variations in PENK and POMC appear to be associated with the narrower phenotype of opioid dependence in these families. © 2007 Wiley-Liss, Inc.