No association of migraine to the GABA-A receptor complex on chromosome 15

Authors

  • G. Oswell,

    1. The Finnish Genome Center, University of Helsinki, Helsinki, Finland
    2. Department of Pathology, David Geffen School of Medicine at UCLA, Los Angeles, California
    3. Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, California
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  • M.A. Kaunisto,

    1. Biomedicum Helsinki, Research Program in Molecular Medicine, University of Helsinki, Helsinki, Finland
    2. Department of Clinical Chemistry, Helsinki University Central Hospital, Helsinki, Finland
    3. Folkhälsan Institute of Genetics, Folkhälsan Research Center, Biomedicum, University of Helsinki, Helsinki, Finland
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  • M. Kallela,

    1. Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland
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  • E. Hämäläinen,

    1. The Finnish Genome Center, University of Helsinki, Helsinki, Finland
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  • V. Anttila,

    1. The Finnish Genome Center, University of Helsinki, Helsinki, Finland
    2. Biomedicum Helsinki, Research Program in Molecular Medicine, University of Helsinki, Helsinki, Finland
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  • J. Kaprio,

    1. Department of Public Health, University of Helsinki, Helsinki, Finland
    2. Department of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, Finland
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  • M. Färkkilä,

    1. Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland
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  • M. Wessman,

    1. Biomedicum Helsinki, Research Program in Molecular Medicine, University of Helsinki, Helsinki, Finland
    2. Department of Clinical Chemistry, Helsinki University Central Hospital, Helsinki, Finland
    3. Folkhälsan Institute of Genetics, Folkhälsan Research Center, Biomedicum, University of Helsinki, Helsinki, Finland
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  • A. Palotie

    Corresponding author
    1. The Finnish Genome Center, University of Helsinki, Helsinki, Finland
    2. Biomedicum Helsinki, Research Program in Molecular Medicine, University of Helsinki, Helsinki, Finland
    3. Department of Clinical Chemistry, Helsinki University Central Hospital, Helsinki, Finland
    4. The Broad Institute of MIT and Harvard, Cambridge, Massachusetts
    • Finnish Genome Center, Haartmaninkatu 8 (P. O. Box 63), 00014 University of Helsinki, Helsinki, Finland.
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  • The authors have reported no conflicts of interest.

  • Please cite this article as follows: Oswell G, Kaunisto MA, Kallela M, Hämäläinen E, Anttila V, Kaprio J, Färkkilä M, Wessman M, Palotie A. 2007. No Association of Migraine to the GABA-A Receptor Complex on Chromosome 15. Am J Med Genet Part B 147B:33–36.

Abstract

To date, no gene variants predisposing to common forms of migraine have been convincingly identified. Recently, significant linkage to a cluster of gamma-amino butyric acid (GABA)-A receptors on Chr 15q11–q13 was reported. We performed an extensive association study using 898 MA cases and 900 matched controls by covering the same gene cluster with 34 single nucleotide polymorphisms (SNPs). No association to MA was detected, suggesting that common variants of the GABA cluster are unlikely to be major contributors of MA susceptibility. © 2007 Wiley-Liss, Inc.

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