Please cite this article as follows: Loo SK, Smalley SL. 2007. Preliminary Report of Familial Clustering of EEG Measures in ADHD. Am J Med Genet Part B 147B:107–109.
Brief Research Communication
Preliminary report of familial clustering of EEG measures in ADHD†
Article first published online: 19 JUN 2007
Copyright © 2007 Wiley-Liss, Inc.
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Volume 147B, Issue 1, pages 107–109, 5 January 2008
How to Cite
Loo, S. K. and Smalley, S. L. (2008), Preliminary report of familial clustering of EEG measures in ADHD. Am. J. Med. Genet., 147B: 107–109. doi: 10.1002/ajmg.b.30575
- Issue published online: 14 DEC 2007
- Article first published online: 19 JUN 2007
- Manuscript Accepted: 9 MAY 2007
- Manuscript Received: 13 FEB 2007
- National Institute of Child Health and Human Development. Grant Number: CD40275
- General Clinical Research Center. Grant Number: M01-RR00865
- alpha power;
The purpose of the present study is to examine the familiality of electroencephalographic (EEG) measures among affected sibling pairs with Attention-Deficit Hyperactivity Disorder (ADHD). EEG was recorded during baseline (eyes open and eyes closed) and cognitive activation conditions on a sample of 58 children with ADHD (27 multiplex families), ages 6–18. EEG power in three frequency bands: theta (4–7 Hz), alpha (8–12 Hz) and beta (12–20 Hz) was tested for sibling correlation, familial co-segregation and association with behavioral task performance on a sustained attention task. Sibling correlation for EEG measures was moderate during baseline conditions and significantly higher for the cognitive activation condition. Familial clustering of frontal and parietal alpha power was evident, but only during the cognitive activation condition. Theta and alpha power correlated significantly with CPT response variability and omission errors, respectively. Cognitive task performance did not exhibit familial clustering in our sample. EEG measures (i.e., alpha power) recorded during cognitive activation is a strongly familial trait in ADHD and may be a putative endophenotype for ADHD. © 2007 Wiley-Liss, Inc.