The BDNF Val66Met × 5-HTTLPR × child adversity interaction and depressive symptoms: An attempt at replication

Authors

  • Marieke Wichers,

    Corresponding author
    1. Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University, Maastricht, The Netherlands
    • Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University, Maastricht, The Netherlands
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  • Gunter Kenis,

    1. Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University, Maastricht, The Netherlands
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  • Nele Jacobs,

    1. Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University, Maastricht, The Netherlands
    2. Faculty of Psychology, Open University of the Netherlands, Heerlen, The Netherlands
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  • Ron Mengelers,

    1. Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University, Maastricht, The Netherlands
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  • Catherine Derom,

    1. Department of Human Genetics, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Leuven, Belgium
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  • Robert Vlietinck,

    1. Department of Human Genetics, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Leuven, Belgium
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  • Jim van Os

    1. Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University, Maastricht, The Netherlands
    2. Division of Psychological Medicine, Institute of Psychiatry, London, UK
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  • Please cite this article as follows: Wichers MC, Kenis G, Jacobs N, Mengelers R, Derom C, Vlietinck R, van Os J. 2007. The BDNF Val66Met × 5-HTTLPR × Child Adversity Interaction and Depressive Symptoms: An Attempt at Replication. Am J Med Genet Part B 147B:120–123.

Abstract

Kaufman et al. [2006] reported a higher order interaction effect between specific genetic and environmental factors in a model of depressive symptoms, requiring independent replication. BDNF Val66Met and 5-HTTLPR genotypes were determined in female participants pertaining to a large ongoing twin study. Participants also filled in questionnaires on childhood adversity and depressive symptoms. Two- and three-way interactions between genetic polymorphisms and early adversity were examined in models of depressive symptoms. BDNF Met allele(s) moderated the effect of early adversity on depressive symptoms (two-way interaction), and this BDNF Met × childhood adversity interaction in turn was moderated by 5-HTTLPR genotype (three-way interaction). However, a main effect of BDNF Met on childhood adversity was also observed, possibly indicating confounding by gene–environment correlation. Higher order interaction effects involving BDNF Val66Met, 5-HTTLPR and childhood adversity may contribute to the etiology of depressive illness. © 2007 Wiley-Liss, Inc.

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