Please cite this article as follows: Banoei MM, Majidizadeh T, Shirazi E, Moghimi N, Ghadiri M, Najmabadi H, Ohadi M. 2007. No Association Between the DAT1 10-Repeat Allele and ADHD in the Iranian Population. Am J Med Genet Part B 147B:110–111.
Brief Research Communication
No association between the DAT1 10-repeat allele and ADHD in the Iranian population†
Article first published online: 20 JUN 2007
Copyright © 2007 Wiley-Liss, Inc.
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Volume 147B, Issue 1, pages 110–111, 5 January 2008
How to Cite
Banoei, M.M., Majidizadeh, T., Shirazi, E., Moghimi, N., Ghadiri, M., Najmabadi, H. and Ohadi, M. (2008), No association between the DAT1 10-repeat allele and ADHD in the Iranian population. Am. J. Med. Genet., 147B: 110–111. doi: 10.1002/ajmg.b.30578
- Issue published online: 14 DEC 2007
- Article first published online: 20 JUN 2007
- Manuscript Accepted: 9 MAY 2007
- Manuscript Received: 7 JAN 2007
Association studies between attention-deficit hyperactivity disorder (ADHD) and the 10-repeat allele of a polymorphism (a 40 bp variable number of tandem repeats) in the dopamine transporter gene (DAT1) have resulted in mixed findings in different populations. We performed a case/control study to clarify the contribution of this allele with ADHD in the Iranian population. No association was observed between the 10-allele and disease (χ2 = 0.081, P < 0.9). Furthermore, no significant difference was observed in the homozygosity of this allele between the case and control groups (χ2 = 0.022, P < 0.9). Implication of the dopamine transporter gene in the pathophysiology of ADHD warrants investigation of other functional polymorphisms within this gene in the Iranian ADHD patients. © 2007 Wiley-Liss, Inc.