Dissocial behavior, the 5HTTLPR polymorphism, and maltreatment in women with bulimic syndromes

Authors

  • Howard Steiger,

    Corresponding author
    1. Eating Disorders Program, Douglas Institute, Montreal, Quebec, Canada
    2. Psychiatry Department, McGill University, Montreal, Quebec, Canada
    3. Research Centre, Douglas Institute, Montreal, Quebec, Canada
    • Eating Disorders Program, Douglas Institute, 6875 LaSalle Blvd., Montreal (Verdun) Quebec, Canada H4H 1R3.
    Search for more papers by this author
  • Jodie Richardson,

    1. Eating Disorders Program, Douglas Institute, Montreal, Quebec, Canada
    2. Research Centre, Douglas Institute, Montreal, Quebec, Canada
    3. Psychology Department, McGill University, Montreal, Quebec, Canada
    Search for more papers by this author
  • Ridha Joober,

    1. Psychiatry Department, McGill University, Montreal, Quebec, Canada
    2. Research Centre, Douglas Institute, Montreal, Quebec, Canada
    Search for more papers by this author
  • Mimi Israel,

    1. Eating Disorders Program, Douglas Institute, Montreal, Quebec, Canada
    2. Psychiatry Department, McGill University, Montreal, Quebec, Canada
    3. Research Centre, Douglas Institute, Montreal, Quebec, Canada
    Search for more papers by this author
  • Kenneth R. Bruce,

    1. Eating Disorders Program, Douglas Institute, Montreal, Quebec, Canada
    2. Psychiatry Department, McGill University, Montreal, Quebec, Canada
    3. Research Centre, Douglas Institute, Montreal, Quebec, Canada
    Search for more papers by this author
  • N.M.K. Ng Ying Kin,

    1. Psychiatry Department, McGill University, Montreal, Quebec, Canada
    2. Research Centre, Douglas Institute, Montreal, Quebec, Canada
    Search for more papers by this author
  • Heidi Howard,

    1. Psychiatry Department, McGill University, Montreal, Quebec, Canada
    2. Research Centre, Douglas Institute, Montreal, Quebec, Canada
    Search for more papers by this author
  • Annelie Anestin,

    1. Eating Disorders Program, Douglas Institute, Montreal, Quebec, Canada
    Search for more papers by this author
  • Cathy Dandurand,

    1. Eating Disorders Program, Douglas Institute, Montreal, Quebec, Canada
    Search for more papers by this author
  • Lise Gauvin

    1. Research Centre, Douglas Institute, Montreal, Quebec, Canada
    2. Department of Social and Preventive Medicine and Groupe de Recherche Interdisciplinaire en Santé (GRIS), University of Montreal, Montreal, Quebec, Canada
    Search for more papers by this author

  • Please cite this article as follows: Steiger H, Richardson J, Joober R, Israel M, Bruce KR, Ng Ying Kin NMK, Howard H, Anestin A, Dandurand C, Gauvin L. 2007. Dissocial Behavior, the 5HTTLPR Polymorphism, and Maltreatment in Women With Bulimic Syndromes. Am J Med Genet Part B 147B:128–130.

Abstract

We recently reported that, among bulimic women, previously abused carriers of the 5HTTLPR S allele showed special propensities towards novelty seeking (implying recklessness or impulsivity) and interpersonal insecurity. We subsequently re-analyzed our data, to examine the bearing of the 5HTTLPR polymorphism and prior sexual or physical maltreatment upon validated, higher-order personality-traits. Ninety women with bulimic syndromes were genotyped for 5HTTLPR “short” (S) and “long” (LG and LA) alleles, and then assessed for eating symptoms, history of sexual or physical abuse, and the higher-order personality traits Emotional Dysregulation, Dissocial Behavior, Inhibition, and Compulsivity. With a classification based on a biallelic model of 5HTTLPR (i.e., presence or absence of at least one S-allele copy), multiple regression indicated a significant proportion of variance in Dissocial Behavior to be explained by an abuse × genotype interaction—greater psychopathology occurring in abused S-allele carriers. A parallel analysis applying a triallelic model of 5HTTLPR (i.e., presence or absence of at least one copy of presumably low-function S or LG alleles) produced a similar pattern, but no statistically significant effect. The finding that bulimic 5HTTLPR S-allele carriers who are previously abused display elevations on Dissocial Behavior corroborates previous observations concerning phenomenological correlates of traumatic stress in 5HTTLPR S allele carriers. © 2007 Wiley-Liss, Inc.

Ancillary