Please cite this article as follows: Steiger H, Richardson J, Joober R, Israel M, Bruce KR, Ng Ying Kin NMK, Howard H, Anestin A, Dandurand C, Gauvin L. 2007. Dissocial Behavior, the 5HTTLPR Polymorphism, and Maltreatment in Women With Bulimic Syndromes. Am J Med Genet Part B 147B:128–130.
Brief Research Communication
Dissocial behavior, the 5HTTLPR polymorphism, and maltreatment in women with bulimic syndromes†
Article first published online: 22 AUG 2007
Copyright © 2007 Wiley-Liss, Inc.
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Volume 147B, Issue 1, pages 128–130, 5 January 2008
How to Cite
Steiger, H., Richardson, J., Joober, R., Israel, M., Bruce, K. R., Ng Ying Kin, N.M.K., Howard, H., Anestin, A., Dandurand, C. and Gauvin, L. (2008), Dissocial behavior, the 5HTTLPR polymorphism, and maltreatment in women with bulimic syndromes. Am. J. Med. Genet., 147B: 128–130. doi: 10.1002/ajmg.b.30579
- Issue published online: 14 DEC 2007
- Article first published online: 22 AUG 2007
- Manuscript Accepted: 4 JUN 2007
- Manuscript Received: 9 APR 2007
- Quebec Government's Joint CQRS-FRSQ-MSSS Program in Mental Health. Grant Number: SR-4306
- Canadian Institutes for Health Research. Grant Number: MOP-57929
- bulimia nervosa;
We recently reported that, among bulimic women, previously abused carriers of the 5HTTLPR S allele showed special propensities towards novelty seeking (implying recklessness or impulsivity) and interpersonal insecurity. We subsequently re-analyzed our data, to examine the bearing of the 5HTTLPR polymorphism and prior sexual or physical maltreatment upon validated, higher-order personality-traits. Ninety women with bulimic syndromes were genotyped for 5HTTLPR “short” (S) and “long” (LG and LA) alleles, and then assessed for eating symptoms, history of sexual or physical abuse, and the higher-order personality traits Emotional Dysregulation, Dissocial Behavior, Inhibition, and Compulsivity. With a classification based on a biallelic model of 5HTTLPR (i.e., presence or absence of at least one S-allele copy), multiple regression indicated a significant proportion of variance in Dissocial Behavior to be explained by an abuse × genotype interaction—greater psychopathology occurring in abused S-allele carriers. A parallel analysis applying a triallelic model of 5HTTLPR (i.e., presence or absence of at least one copy of presumably low-function S or LG alleles) produced a similar pattern, but no statistically significant effect. The finding that bulimic 5HTTLPR S-allele carriers who are previously abused display elevations on Dissocial Behavior corroborates previous observations concerning phenomenological correlates of traumatic stress in 5HTTLPR S allele carriers. © 2007 Wiley-Liss, Inc.