J. Sandra Kooij has been a consultant to/member of advisory board of/and/or speaker for Janssen Cilag BV and Eli Lilly.
Response to methylphenidate in adults with ADHD is associated with a polymorphism in SLC6A3 (DAT1)†
Article first published online: 22 OCT 2007
Copyright © 2007 Wiley-Liss, Inc.
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Volume 147B, Issue 2, pages 201–208, 5 March 2008
How to Cite
Kooij, J. S., Boonstra, A. M., Vermeulen, S. H., Heister, A. G., Burger, H., Buitelaar, J. K. and Franke, B. (2008), Response to methylphenidate in adults with ADHD is associated with a polymorphism in SLC6A3 (DAT1). Am. J. Med. Genet., 147B: 201–208. doi: 10.1002/ajmg.b.30586
Please cite this article as follows: Kooij JS, Boonstra AM, Vermeulen SH, Heister AG, Burger H, Buitelaar JK, Franke B. 2008. Response to Methylphenidate in Adults With ADHD is Associated With a Polymorphism in SLC6A3 (DAT1). Am J Med Genet Part B 147B:201–208.
- Issue published online: 21 FEB 2008
- Article first published online: 22 OCT 2007
- Manuscript Accepted: 15 JUN 2007
- Manuscript Received: 19 FEB 2007
- medication response;
- dopamine transporter SLC6A3 (DAT1)
In this pharmacogenetic study in adults with ADHD (n = 42), a stratified analysis was performed of the association between response to methylphenidate (MPH), assessed under double-blind conditions, and polymorphisms in the genes encoding the dopamine transporter, SLC6A3 (DAT1), the norepinephrine transporter, SLC6A2 (NET), and the dopamine receptor D4, DRD4. The VNTR polymorphism in the 3′ untranslated region of SLC6A3 was significantly associated with an increased likelihood of a response to MPH treatment (OR 3.8; 95% CI 1.0–15.2, and OR 5.4; 95% CI 1.4–21.9, depending on the definition of response) in carriers of a single 10-repeat allele compared to patients with the 10/10 genotype. The polymorphisms in DRD4 and the SLC6A2 were not associated with treatment response. This study supports a role of the SLC6A3 genotype in determining the response to MPH in the treatment of adults with ADHD. © 2007 Wiley-Liss, Inc.