Please cite this article as follows: Toulopoulou T, Chua SE, Lam I, Cheung V, Murray RM, David AS. 2007. Evidence of Normal Hearing Laterality in Familial Schizophrenic Patients and Their Relatives. Am J Med Genet Part B 147B:73–76.
Evidence of normal hearing laterality in familial schizophrenic patients and their relatives†
Article first published online: 22 AUG 2007
Copyright © 2007 Wiley-Liss, Inc.
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Volume 147B, Issue 1, pages 73–76, 5 January 2008
How to Cite
Toulopoulou, T., Chua, S. E., Lam, I., Cheung, V., Murray, R. M. and David, A. S. (2008), Evidence of normal hearing laterality in familial schizophrenic patients and their relatives. Am. J. Med. Genet., 147B: 73–76. doi: 10.1002/ajmg.b.30587
- Issue published online: 14 DEC 2007
- Article first published online: 22 AUG 2007
- Manuscript Accepted: 15 JUN 2007
- Manuscript Received: 23 JAN 2007
- cerebral laterality;
- dichotic listening
Dichotic listening (DL) has been used as a tool to investigate possible left cerebral dysfunction in schizophrenia. However, the wide range of DL tests (e.g., words, emotions, sentences) as well as patient groups (“heterogeneity”) has introduced several confounders. Assessing relatives of patients with schizophrenia may overcome some of these problems, and may be more useful in determining if loss of functional cerebral laterality in schizophrenia is a state or a trait phenomenon. The fused consonant-vowel DL test was administered to 114 subjects: 20 individuals with familial schizophrenia, 42 of their healthy relatives, and 52 healthy volunteers. We did this to investigate whether the normal language processing asymmetry—a right ear advantage (REA)—is present, and whether it could serve as a marker for genetic liability. General performance accuracy level was lower in schizophrenia patients and their relatives but the expected REA was present in all groups. Adjusting for age, accuracy, and obligate status made no difference. In conclusion, familial schizophrenic patients and their relatives have normal REA and hearing laterality on the fused DL test. © 2007 Wiley-Liss, Inc.