Please cite this article as follows: Giegling I, Moreno-De-Luca D, Rujescu D, Schneider B, Hartmann AM, Schnabel A, Maurer K, Möller H-J, Serretti A. 2008. Dopa Decarboxylase and Tyrosine Hydroxylase Gene Variants in Suicidal Behavior. Am J Med Genet Part B 147B: 308–315.
Dopa decarboxylase and tyrosine hydroxylase gene variants in suicidal behavior†
Version of Record online: 19 OCT 2007
Copyright © 2007 Wiley-Liss, Inc.
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Volume 147B, Issue 3, pages 308–315, 5 April 2008
How to Cite
Giegling, I., Moreno-De-Luca, D., Rujescu, D., Schneider, B., Hartmann, A. M., Schnabel, A., Maurer, K., Möller, H.-J. and Serretti, A. (2008), Dopa decarboxylase and tyrosine hydroxylase gene variants in suicidal behavior. Am. J. Med. Genet., 147B: 308–315. doi: 10.1002/ajmg.b.30599
- Issue online: 21 MAR 2008
- Version of Record online: 19 OCT 2007
- Manuscript Accepted: 21 JUN 2007
- Manuscript Received: 22 JAN 2007
- tyrosine hydroxylase;
- dopa decarboxylase;
- dopamine synthesis
The dopaminergic system has been previously associated to behavioral facilitation and aggression, hence making the pathway a good candidate for suicidal behavior. We studied gene variants in the tyrosine hydroxylase (rs3842727, rs6356) and DOPA decarboxylase (rs1451371, rs1470750, rs998850) genes in a sample of 571 individuals consisting of 167 German suicide attempters (affective spectrum n = 107, schizophrenia spectrum n = 35, borderline personality disorder n = 25), 92 Caucasian individuals who committed suicide and 312 German control subjects. TH variants were not associated with suicide (uncorrected P = 0.023) and related traits. Some marginal associations could be observed for DDC with suicide, violence, anger, and aggression. In conclusion, our study does not support the involvement of TH gene variants as major contributors to suicide, whereas DDC variants could mediate some features related to suicide and be involved in violent suicidal behavior. © 2007 Wiley-Liss, Inc.