Brief Research Communication

The neuregulin 1 promoter polymorphism rs6994992 is not associated with chronic schizophrenia or neurocognition†

  1. James J. Crowley1,*,
  2. Richard S.E. Keefe2,
  3. Diana O. Perkins3,
  4. T. Scott Stroup3,
  5. Jeffrey A. Lieberman4,
  6. Patrick F. Sullivan1,3,5

Article first published online: 19 FEB 2008

DOI: 10.1002/ajmg.b.30727

Issue

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

Volume 147B, Issue 7, pages 1298–1300, 5 October 2008

Additional Information

How to Cite

Crowley, J. J., Keefe, R. S.E., Perkins, D. O., Stroup, T. S., Lieberman, J. A. and Sullivan, P. F. (2008), The neuregulin 1 promoter polymorphism rs6994992 is not associated with chronic schizophrenia or neurocognition. Am. J. Med. Genet., 147B: 1298–1300. doi: 10.1002/ajmg.b.30727

Author Information

  1. 1

    Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina

  2. 2

    Department of Psychiatry, Duke University, Durham, North Carolina

  3. 3

    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina

  4. 4

    Department of Psychiatry, Columbia University, New York, New York

  5. 5

    Department of Medical Epidemiology & Biostatistics, Karolinska Institutet, Stockholm, Sweden

*Department of Genetics, CB#7264, 4113 Neurosciences Research Building, University of North Carolina, Chapel Hill, NC 27599-7264.

  1. †

    Please cite this article as follows: Crowley JJ, Keefe RSE, Perkins DO, Stroup TS, Lieberman JA, Sullivan PF. 2008. The Neuregulin 1 Promoter Polymorphism rs6994992 Is Not Associated With Chronic Schizophrenia or Neurocognition. Am J Med Genet Part B 147B:1298–1300.

Publication History

  1. Issue published online: 18 SEP 2008
  2. Article first published online: 19 FEB 2008
  3. Manuscript Accepted: 9 JAN 2008
  4. Manuscript Received: 24 SEP 2007

Funded by

  • NIMH Contract. Grant Number: NO1 MH90001

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Keywords:

  • schizophrenia;
  • NRG1;
  • rs6994992;
  • neurocognition;
  • association study

Abstract

The neuregulin 1 (NRG1) promoter single nucleotide polymorphism (SNP) rs6994992 has shown association with decreased activation of frontal and temporal lobe regions, increased risk of psychosis, and decreased premorbid IQ. This SNP is part of a putative schizophrenia risk-associated haplotype and was associated with increased expression of the type IV transcript in postmortem tissue. We tested for association between rs6994992 and chronic schizophrenia by genotyping 738 cases from the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) and 733 matched controls. We further tested for associations with age at onset and baseline neurocognition in cases with schizophrenia reasoning that these phenotypes might yield results similar to those seen for premorbid IQ. Affection status was weakly associated with rs6994992 genotypes and trended towards association under a recessive model. This association did not survive correction for multiple comparisons and was in the opposite direction than has been reported. There was no association between rs6994992 and age at onset, an estimate of premorbid IQ, or neurocognition at study baseline. We were unable to replicate previous associations of rs6994992 with schizophrenia and, moreover, did not find significant associations with age of onset, an estimate of pre-morbid IQ, or neurocognition. © 2008 Wiley-Liss, Inc.

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