Please cite this article as follows: Legallic S, Bou J, Haouzir S, Allio G, Demily C, Petit M, Frebourg T, Thibaut F, Campion D. 2008. No Pathogenic Rearrangement Within the DISC 1 Gene in Psychosis. Am J Med Genet Part B 150B:148–150.
Brief Research Communication
No pathogenic rearrangement within the DISC 1 gene in psychosis†
Version of Record online: 7 APR 2008
Copyright © 2008 Wiley-Liss, Inc.
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Volume 150B, Issue 1, pages 148–150, 5 January 2009
How to Cite
Legallic, S., Bou, J., Haouzir, S., Allio, G., Demily, C., Petit, M., Frebourg, T., Thibaut, F. and Campion, D. (2009), No pathogenic rearrangement within the DISC 1 gene in psychosis. Am. J. Med. Genet., 150B: 148–150. doi: 10.1002/ajmg.b.30753
- Issue online: 21 JAN 2009
- Version of Record online: 7 APR 2008
- Manuscript Accepted: 20 FEB 2008
- Manuscript Received: 28 SEP 2007
A translocation disrupting the DISC 1 gene segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Mutation screening of this gene by routine PCR-based methods has remained largely negative. We sought to detect rearrangements affecting DISC 1 in 347 individuals meeting the DSM3R criteria for schizophrenia or schizoaffective disorder, 70 subjects with bipolar disorder and 377 psychiatrically healthy controls, but failed to detect any pathological rearrangement. © 2008 Wiley-Liss, Inc.