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No pathogenic rearrangement within the DISC 1 gene in psychosis


  • Please cite this article as follows: Legallic S, Bou J, Haouzir S, Allio G, Demily C, Petit M, Frebourg T, Thibaut F, Campion D. 2008. No Pathogenic Rearrangement Within the DISC 1 Gene in Psychosis. Am J Med Genet Part B 150B:148–150.


A translocation disrupting the DISC 1 gene segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Mutation screening of this gene by routine PCR-based methods has remained largely negative. We sought to detect rearrangements affecting DISC 1 in 347 individuals meeting the DSM3R criteria for schizophrenia or schizoaffective disorder, 70 subjects with bipolar disorder and 377 psychiatrically healthy controls, but failed to detect any pathological rearrangement. © 2008 Wiley-Liss, Inc.