Please cite this article as follows: Morgan AR, Hollingworth P, Abraham R, Lovestone S, Brayne C, Rubinsztein DC, Lynch A, Lawlor B, Gill M, O'Donovan MC, Owen MJ, Williams J. 2008. Association Analysis of Dynamin-Binding Protein (DNMBP) on Chromosome 10q With Late Onset Alzheimer's Disease in a Large Caucasian UK Sample. Am J Med Genet Part B 150B:61–64.
Association analysis of dynamin-binding protein (DNMBP) on chromosome 10q with late onset Alzheimer's disease in a large caucasian UK sample†
Article first published online: 1 MAY 2008
Copyright © 2008 Wiley-Liss, Inc.
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Volume 150B, Issue 1, pages 61–64, 5 January 2009
How to Cite
Morgan, A.R., Hollingworth, P., Abraham, R., Lovestone, S., Brayne, C., Rubinsztein, D.C., Lynch, A., Lawlor, B., Gill, M., O'Donovan, M.C., Owen, M.J. and Williams, J. (2009), Association analysis of dynamin-binding protein (DNMBP) on chromosome 10q with late onset Alzheimer's disease in a large caucasian UK sample. Am. J. Med. Genet., 150B: 61–64. doi: 10.1002/ajmg.b.30768
- Issue published online: 21 JAN 2009
- Article first published online: 1 MAY 2008
- Manuscript Accepted: 25 MAR 2008
- Manuscript Received: 8 JAN 2008
- Medical Research Council, UK
- Alzheimer's Research Trust, UK
- late-onset Alzheimer's disease;
- chromosome 10;
A recent scan of single nucleotide polymorphisms (SNPs) in the region 40–107 Mb on chromosome 10q in a large Japanese case–control cohort identified six SNPs in or near the dynamin-binding protein gene (DNMBP) that were associated with late onset Alzheimer's disease (LOAD) in individuals lacking the APOE ε4 allele [Kuwano et al. (2006); Hum Mol Genet 15:2170–2182]. We genotyped these six SNPs in 1,212 unrelated Caucasian patients of UK origin with LOAD and 1,389 ethnically, gender and age matched control subjects. We did not observe a statistically significant association with the risk of LOAD for any of the six SNPs in the sample as a whole. When stratifying the sample by APOE one SNP (intergenic SNP rs11190302) was associated with LOAD in individuals lacking the ε4 allele (genotypic P = 0.027, allelic P = 0.066). However this association was in the opposite direction to that detected in the Japanese population. It remains to be determined whether DNMBP is associated with LOAD. © 2008 Wiley-Liss, Inc.