Please cite this article as follows: Barlas IO, Cetin M, Erdal ME, Semiz UB, Basoglu C, Ay ME, Herken H, Uzun O. 2008. Lack of Association Between DRD3 Gene Polymorphism and Response to Clozapine in Turkish Schizoprenia Patients. Am J Med Genet Part B 150B:56–60.
Lack of association between DRD3 gene polymorphism and response to clozapine in Turkish schizoprenia patients†
Article first published online: 30 APR 2008
Copyright © 2008 Wiley-Liss, Inc.
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Volume 150B, Issue 1, pages 56–60, 5 January 2009
How to Cite
Barlas, I. O., Cetin, M., Erdal, M. E., Semiz, U. B., Basoglu, C., Ay, M. E., Herken, H. and Uzun, O. (2009), Lack of association between DRD3 gene polymorphism and response to clozapine in Turkish schizoprenia patients. Am. J. Med. Genet., 150B: 56–60. doi: 10.1002/ajmg.b.30770
- Issue published online: 21 JAN 2009
- Article first published online: 30 APR 2008
- Manuscript Accepted: 26 MAR 2008
- Manuscript Received: 10 DEC 2007
- dopamine D3 receptor gene (DRD3);
It is hypothesized that molecular components of dopaminergic system, especially the dopamine D3 receptor gene (DRD3), may play a crucial role in the pathophysiology of schizophrenia, because it is abundant in the limbic system of the brain and it binds antipsychotic drugs. Several groups attempted to find an association between a serine-to-glycine polymorphism of the DRD3 gene (Ser9Gly) and schizophrenia; however, the results were inconsistent. In this study, we aimed to investigate the relationship of the Serine/Glycine polymorphism of the DRD3 gene with therapeutic response to clozapine treatment between Turkish schizophrenia patients (N = 92) and healthy controls (N = 100). Genotype groups were comparable in BPRS, SAPS, SANS analysis of response to clozapine. Our results suggest that an association between the Ser/Gly polymorphism of DRD3 gene and response to clozapine in Turkish schizophrenia patients is unlikely to exist. © 2008 Wiley-Liss, Inc.