This article is a US Government work and, as such, is in the public domain in the United States of America.
Article first published online: 15 MAY 2008
Published 2008 Wiley-Liss, Inc.
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Volume 150B, Issue 1, pages 1–11, 5 January 2009
How to Cite
Chadman, K. K., Yang, M. and Crawley, J. N. (2009), Criteria for validating mouse models of psychiatric diseases. Am. J. Med. Genet., 150B: 1–11. doi: 10.1002/ajmg.b.30777
Please cite this article as follows: Chadman KK, Yang M, Crawley JN. 2008. Criteria for Validating Mouse Models of Psychiatric Diseases. Am J Med Genet Part B 150B:1–11.
- Issue published online: 21 JAN 2009
- Article first published online: 15 MAY 2008
- Manuscript Accepted: 1 APR 2008
- Manuscript Received: 13 FEB 2008
Animal models of human diseases are in widespread use for biomedical research. Mouse models with a mutation in a single gene or multiple genes are excellent research tools for understanding the role of a specific gene in the etiology of a human genetic disease. Ideally, the mouse phenotypes will recapitulate the human phenotypes exactly. However, exact matches are rare, particularly in mouse models of neuropsychiatric disorders. This article summarizes the current strategies for optimizing the validity of a mouse model of a human brain dysfunction. We address the common question raised by molecular geneticists and clinical researchers in psychiatry, “what is a ‘good enough’ mouse model”11 Published 2008 Wiley-Liss, Inc.