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Angiotensin I-converting enzyme I/D polymorphism and suicidal behaviors

Authors

  • D. Larry Sparks,

    1. Sun Health Research Institute, Sun City, Arizona
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  • John C. Hunsaker III,

    1. Division of Medical Examiner's Services, Kentucky Justice Cabinet, Frankfort, Kentucky
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  • Philippe Amouyel,

    Corresponding author
    1. INSERM, U744, Lille, France; Institut Pasteur de Lille, Lille, France; University of Lille 2, Lille, France
    2. Centre Hospitalier et Universitaire de Lille, Lille, France
    • Service d'Epidémiologie et de Santé Publique, INSERM, U744, Institut Pasteur de Lille, 1 rue Calmette, BP 245, 59019 Lille Cedex, France.
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  • Alain Malafosse,

    1. Department of Medical Genetics and Development, School of Medicine, Geneva, Switzerland
    2. INSERM, U888; University of Montpellier I, Montpellier, France
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  • Franck Bellivier,

    1. INSERM, U841; IMRB, Department of Genetics, Psychiatry Genetics, Créteil, France
    2. Université Paris 12, Faculty of Medicine, IFR10, Créteil, France
    3. AP-HP, Groupe Henri Mondor-Albert Chenevier, Département Hospitalo-Universitaire de Psychiatrie, Créteil, France
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  • Marion Leboyer,

    1. INSERM, U841; IMRB, Department of Genetics, Psychiatry Genetics, Créteil, France
    2. Université Paris 12, Faculty of Medicine, IFR10, Créteil, France
    3. AP-HP, Groupe Henri Mondor-Albert Chenevier, Département Hospitalo-Universitaire de Psychiatrie, Créteil, France
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  • Philippe Courtet,

    1. INSERM, U888; University of Montpellier I, Montpellier, France
    2. University of Montpellier I, Montpellier, France
    3. Department of Psychological Medicine and Psychiatry, Lapeyronie Hospital, University Hospital of Montpellier, Montpellier, France
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  • Nicole Helbecque

    1. INSERM, U744, Lille, France; Institut Pasteur de Lille, Lille, France; University of Lille 2, Lille, France
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  • Please cite this article as follows: Sparks DL, Hunsaker JC, Amouyel P, Malafosse A, Bellivier F, Leboyer M, Courtet P, Helbecque N. 2009. Angiotensin I-Converting Enzyme I/D Polymorphism and Suicidal Behaviors. Am J Med Genet Part B 150B:290–294.

Abstract

Suicide is one of the ten most common causes of death in Western countries. It involves genetic vulnerability factors and is often associated with major depression. A Japanese team reported an association between the insertion allele of the angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism with completed suicide. The ACE I/D polymorphism was investigated in two independent case-control studies, one involving 64 suicide completers and 90 controls who all underwent forensic investigations, the second one consisting of 588 suicide attempters and 639 controls. In the two population samples studied a statistically significant risk of suicidal behavior was observed for subjects bearing the DD genotype. These results suggest a possible role of the renin-angiotensin system in suicidal behavior. © 2008 Wiley-Liss, Inc.

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