Association study between the PIK4CA gene and methamphetamine use disorder in a Japanese population

Authors

  • Nobuhisa Kanahara,

    1. Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
    2. Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan
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  • Ryosuke Miyatake,

    1. Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
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  • Yoshimoto Sekine,

    1. Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    2. Japanese Genetics Initiative for Drug Abuse (JGIDA), Okayama, Japan
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  • Toshiya Inada,

    1. Japanese Genetics Initiative for Drug Abuse (JGIDA), Okayama, Japan
    2. Seiwa Hospital, Institute of Neuropsychiatry, Tokyo, Japan
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  • Norio Ozaki,

    1. Japanese Genetics Initiative for Drug Abuse (JGIDA), Okayama, Japan
    2. Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan
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  • Nakao Iwata,

    1. Japanese Genetics Initiative for Drug Abuse (JGIDA), Okayama, Japan
    2. Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Japan
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  • Mutsuo Harano,

    1. Japanese Genetics Initiative for Drug Abuse (JGIDA), Okayama, Japan
    2. Department of Neuropsychiatry, Kurume University School of Medicine, Kurume, Japan
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  • Tokutaro Komiyama,

    1. Japanese Genetics Initiative for Drug Abuse (JGIDA), Okayama, Japan
    2. Department of Psychiatry, National Center Hospital for Mental, Nervous and Muscular Disorders, National Center of Neurology and Psychiatry, Kodaira, Japan
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  • Mitsuhiko Yamada,

    1. Japanese Genetics Initiative for Drug Abuse (JGIDA), Okayama, Japan
    2. National Institute of Mental Health, National Center of Neurology and Psychiatry, Kodaira, Japan
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  • Ichiro Sora,

    1. Japanese Genetics Initiative for Drug Abuse (JGIDA), Okayama, Japan
    2. Department of Psychobiology, Tohoku University Graduate School of Medicine, Sendai, Japan
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  • Hiroshi Ujike,

    1. Japanese Genetics Initiative for Drug Abuse (JGIDA), Okayama, Japan
    2. Department of Neuropsychiatry, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
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  • Masaomi Iyo,

    1. Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
    2. Japanese Genetics Initiative for Drug Abuse (JGIDA), Okayama, Japan
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  • Kenji Hashimoto

    Corresponding author
    1. Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan
    • Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, 1-8-1 Inohana, Chiba 260-8670, Japan.
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  • Please cite this article as follows: Kanahara N, Miyatake R, Sekine Y, Inada T, Ozaki N, Iwata N, Harano M, Komiyama T, Yamada M, Sora I, Ujike H, Iyo M, Hashimoto K. 2009. Association Study Between the PIK4CA Gene and Methamphetamine Use Disorder in a Japanese Population. Am J Med Genet Part B 150B:233–238.

Abstract

Accumulating evidence suggests that phosphatidylinositol (PI) pathways have been involved in the secretion of dopamine (DA) and the regulation of DA transporter, which is a target of methamphetamine (METH). A recent large-scale gene-association study in a Dutch population demonstrated that the PIK4CA gene was closely linked to schizophrenia [Jungerius et al. (2007); Mol Psychiatry]. Here, we conducted a case (N = 232)–control (N = 233) study of the PIK4CA gene on Japanese METH abusers, which can manifest severe psychosis similar to schizophrenia. The genotype and allelic distributions of all four single nucleotide polymorphisms (SNPs) did not differ significantly between the METH abusers and the controls. The comparisons based on the classification of the psychosis as transient or prolonged and on the presence or absence of spontaneous relapse revealed no significant distribution of the four SNPs compared to the controls. Furthermore, haplotype analyses showed almost the same frequencies between the METH abusers and the controls. The present study suggests that the PIK4CA gene does not play a significant role in the vulnerability to METH use disorder in the Japanese population. © 2008 Wiley-Liss, Inc.

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