Please cite this article as follows: Kim HW, Cho SC, Kim JW, Cho IH, Kim SA, Park M, Cho EJ, Yoo HJ. 2009. Family-Based Association Study Between NOS-I and -IIA Polymorphisms and Autism Spectrum Disorders in Korean Trios. Am J Med Genet Part B 150B:300–306.
Brief Research Communication
Family-based association study between NOS-I and -IIA polymorphisms and autism spectrum disorders in Korean trios†
Article first published online: 18 JUN 2008
Copyright © 2008 Wiley-Liss, Inc.
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Volume 150B, Issue 2, pages 300–306, 5 March 2009
How to Cite
Kim, H.-W., Cho, S.-C., Kim, J.-W., Cho, I. H., Kim, S. A., Park, M., Cho, E. J. and Yoo, H.-J. (2009), Family-based association study between NOS-I and -IIA polymorphisms and autism spectrum disorders in Korean trios. Am. J. Med. Genet., 150B: 300–306. doi: 10.1002/ajmg.b.30798
- Issue published online: 19 FEB 2009
- Article first published online: 18 JUN 2008
- Manuscript Accepted: 2 MAY 2008
- Manuscript Received: 11 MAR 2008
- autism spectrum disorders (ASD);
- candidate gene study;
- nitric oxide synthase type I (NOS-I);
- nitric oxide synthase type IIA (NOS-IIA)
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder with a strong genetic component and environmental risk factors. Nitric oxide (NO), which is produced by nitric oxide synthase (NOS), may play a role in the development of ASD. We genotyped nine single nucleotide polymorphisms (SNPs) in the NOS-I gene and nine SNPs in the NOS-IIA gene and carried out the transmission disequilibrium test (TDT) and haplotype analysis in 151 Korean ASD trios. We found preferential transmission of the A allele of rs8068149 (P = 0.039) and G allele of rs1060826 (P = 0.035) of NOS-IIA in ASD and the haplotype analysis revealed that the two haplotypes had significant associations (P = 0.014 and 0.031, respectively). The behavioral subdomain score of failure to use nonverbal behaviors to regulate social interaction in Autism Diagnostic Interview-Revised (ADI-R) was significantly higher in subjects with the GG or AG allele in rs1060826 of NOS-IIA compared to those who had the AA allele (P = 0.027). These results provide significant but weak evidence for an association between NOS-IIA and ASD in the Korean population. © 2008 Wiley-Liss, Inc.