Please cite this article as follows: Kazuno A, Munakata K, Mori K, Nanko S, Kunugi H, Nakamura K, Mori N, Yamada K, Yoshikawa T, Kato N, Kato T. 2009. Mitochondrial DNA Haplogroup Analysis in Patients With Bipolar Disorder. Am J Med Genet Part B 150B:243–247.
Mitochondrial DNA haplogroup analysis in patients with bipolar disorder†
Article first published online: 10 JUN 2008
Copyright © 2008 Wiley-Liss, Inc.
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Volume 150B, Issue 2, pages 243–247, 5 March 2009
How to Cite
Kazuno, A.-a., Munakata, K., Mori, K., Nanko, S., Kunugi, H., Nakamura, K., Mori, N., Yamada, K., Yoshikawa, T., Kato, N. and Kato, T. (2009), Mitochondrial DNA haplogroup analysis in patients with bipolar disorder. Am. J. Med. Genet., 150B: 243–247. doi: 10.1002/ajmg.b.30804
- Issue published online: 19 FEB 2009
- Article first published online: 10 JUN 2008
- Manuscript Accepted: 7 MAY 2008
- Manuscript Received: 15 JAN 2008
- Japanese Ministry of Education, Culture, Sports, Science and Technology
- association study;
- bipolar disorder;
- entire mitochondrial DNA sequence;
- mitochondrial DNA haplogroup;
Several lines of evidence support mitochondrial dysfunction in bipolar disorder. Elevated calcium level in platelets is reported in this disease. To verify mitochondrial DNA (mtDNA) haplogroups characteristic to bipolar disorder, we sequenced mtDNA of seven regions and performed haplogroup analysis in 195 patients with bipolar disorder and 255 controls. They belonged to 16 major mtDNA haplogroups, A, B4, B5, C, D4, D5, F, G, M7, M8, M9, M10-12, N9a, N9b, Y, and Z. The logistic regression analysis revealed that the haplogroup N9a was over-represented in bipolar disorder. We also performed a case–control study for two functional mtDNA polymorphisms, mtDNA5460G > A and 12358A > G, that altered intracellular calcium dynamics. While the mtDNA5460G > A polymorphism was not associated with bipolar disorder, the mtDNA12358A > G polymorphism was associated with bipolar disorder in 199 patients with bipolar disorder and 260 controls. However, this association was not replicated in an independent sample set. Possible significances of these findings are discussed. © 2008 Wiley-Liss, Inc.