Please cite this article as follows: Munafò MR, Freimer NB, Ng W, Ophoff R, Veijola J, Miettunen J, Järvelin M-R, Taanila A, Flint J. 2009. 5-HTTLPR Genotype and Anxiety-Related Personality Traits: A Meta-Analysis and New Data. Am J Med Genet Part B 150B:271–281.
5-HTTLPR genotype and anxiety-related personality traits: A meta-analysis and new data†
Article first published online: 10 JUN 2008
Copyright © 2008 Wiley-Liss, Inc.
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Volume 150B, Issue 2, pages 271–281, 5 March 2009
How to Cite
Munafò, M. R., Freimer, N. B., Ng, W., Ophoff, R., Veijola, J., Miettunen, J., Järvelin, M.-R., Taanila, A. and Flint, J. (2009), 5-HTTLPR genotype and anxiety-related personality traits: A meta-analysis and new data. Am. J. Med. Genet., 150B: 271–281. doi: 10.1002/ajmg.b.30808
- Issue published online: 19 FEB 2009
- Article first published online: 10 JUN 2008
- Manuscript Accepted: 8 MAY 2008
- Manuscript Received: 15 FEB 2008
- NIH. Grant Number: 5RL1MH083268-02
- harm avoidance
We investigated the strength of evidence for association of the 5-HTTLPR polymorphism and the personality trait of Harm Avoidance. We used new primary data from a large sample of adults drawn from the Finnish population. We also applied meta-analytic techniques to synthesize existing published data. The large number of studies of the 5-HTTLPR polymorphism allowed us to apply a formal test of publication bias, as well as formally investigate the impact of potential moderating factors such as measurement instrument. Univariate ANOVA of primary data (n = 3,872), with 5-HTTLPR genotype as a between-groups factor, indicated no evidence of association with Harm Avoidance (P = 0.99). Meta-analysis indicated no evidence of significant association of 5-HTTLPR with Harm Avoidance (d = 0.02, P = 0.37), or EPQ Neuroticism (d = 0.01, P = 0.71), although there was evidence of association with NEO Neuroticism (d = 0.18, P < 0.001). Our analyses indicate that the 5-HTTLPR variant is not associated with Harm Avoidance. Together with our previous analyses of a large sample of participants with extreme Neuroticism scores (defined by the EPQ), we have data that excludes a meaningful genetic effect of the 5-HTTLPR on two measures of anxiety-related personality traits. There remains the possibility that the variant influences the NEO personality questionnaire measure of Neuroticism. However, a large, well-powered primary study is required to test this hypothesis directly and adequately. © 2008 Wiley-Liss, Inc.