Please cite this article as follows: Kéri S, Kiss I, Seres I, Kelemen O. 2009. A Polymorphism of the Neuregulin 1 Gene (SNP8NRG243177/rs6994992) Affects Reactivity to Expressed Emotion in Schizophrenia. Am J Med Genet Part B 150B:418–420.
Brief Research Communication
A polymorphism of the neuregulin 1 gene (SNP8NRG243177/rs6994992) affects reactivity to expressed emotion in schizophrenia†
Article first published online: 9 JUN 2008
Copyright © 2008 Wiley-Liss, Inc.
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Volume 150B, Issue 3, pages 418–420, 5 April 2009
How to Cite
Kéri, S., Kiss, I., Seres, I. and Kelemen, O. (2009), A polymorphism of the neuregulin 1 gene (SNP8NRG243177/rs6994992) affects reactivity to expressed emotion in schizophrenia. Am. J. Med. Genet., 150B: 418–420. doi: 10.1002/ajmg.b.30812
- Issue published online: 17 MAR 2009
- Article first published online: 9 JUN 2008
- Manuscript Accepted: 16 MAY 2008
- Manuscript Received: 24 MAR 2008
- Hungarian Research Fund (OTKA). Grant Number: NF72488
- European Twin Study Network on Schizophrenia (EUTwinsS). Grant Number: 035987-1
- neuregulin 1;
- expressed emotion;
- psychosocial stress
A single nucleotide polymorphism of the neuregulin 1 gene (SNP8NRG243177/rs6994992) increases the risk of psychosis, affects prefrontal activation and structural connectivity in the brain, and is related to the expression of a specific neuregulin 1 isoform. The purpose of this study was to investigate the interaction between this polymorphism and reactivity to psychosocial stress. Two hundred patients with schizophrenia were genotyped. The patients and one of their family members participated in neutral and conflict-related interactions in which the number of relatives' criticisms and patients' unusual thoughts was assessed. Patients with the risk T/T genotype expressed more unusual thoughts than C-carriers (C/T and C/C) during conflict-related interactions but not during neutral interactions. Two controls polymorphisms of the neuregulin 1 gene (rs10954867 and rs7005288) showed no such effect. These results raise the possibility that there is a significant gene by environment interaction regarding SNP8NRG243177/rs6994992 and psychosocial stress. © 2008 Wiley-Liss, Inc.