Research Article

Genetic predictors of depressive symptoms in cardiac patients†‡

  1. Jeanne M. McCaffery1,*,
  2. Qing Ling Duan2,
  3. Nancy Frasure-Smith1,3,4,
  4. Amina Barhdadi5,
  5. Francois Lespérance6,
  6. Pierre Théroux7,
  7. Guy A. Rouleau8,
  8. Marie-Pierre Dubé5

Article first published online: 10 JUL 2008

DOI: 10.1002/ajmg.b.30824

Issue

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

Volume 150B, Issue 3, pages 381–388, 5 April 2009

Additional Information

How to Cite

McCaffery, J. M., Duan, Q. L., Frasure-Smith, N., Barhdadi, A., Lespérance, F., Théroux, P., Rouleau, G. A. and Dubé, M.-P. (2009), Genetic predictors of depressive symptoms in cardiac patients. Am. J. Med. Genet., 150B: 381–388. doi: 10.1002/ajmg.b.30824

Author Information

  1. 1

    Weight Control and Diabetes Research Center, Brown Medical School and The Miriam Hospital

  2. 2

    Department of Human Genetics, McGill University

  3. 3

    Department of Psychiatry and School of Nursing, McGill University; the Research Center, Montreal Heart Institute

  4. 4

    Department of Psychiatry, University of Montreal; and the Research Center, Centre Hospitalier de l'Université de Montréal

  5. 5

    Department of Medicine, Université de Montréal and the Research Center of the Montreal Heart Institute

  6. 6

    Department of Psychiatry, Centre Hospitalier de l'Université de Montréal

  7. 7

    Montreal Heart Institute and the University of Montreal

  8. 8

    Department of Medicine, University of Montreal; and the Research Center, Centre Hospitalier de l'Université de Montréal

*Weight Control and Diabetes Research Center, 196 Richmond Street, Providence, RI 02903.

  1. †

    Dr. Frasure-Smith has reported receiving grant support from IsodisNatura and GlaxoSmithKline, and honoraria from Solvay and Tromsdorff. Along with Dr. Lespérance she received placebo and active medication from Lundbeck, Canada for an investigator-initiated, peer-reviewed funded trial. Dr. Lespérance has reported receiving honoraria from GlaxoSmithKline, Lundbeck, and Wyeth and grant support from IsodisNatura and GlaxoSmithKline. He is a consultant for Servier. Dr. McCaffery, Dr. Duan, Dr. Barhdadi, Dr. Théroux, Dr. Rouleau and Dr. Dubé report no relevant conflicts.

  2. ‡

    Please cite this article as follows: McCaffery JM, Duan QL, Frasure-Smith N, Barhdadi A, Lespérance F, Théroux P, Rouleau GA, Dubé M-P. 2009. Genetic Predictors of Depressive Symptoms in Cardiac Patients. Am J Med Genet Part B 150B:381–388.

Publication History

  1. Issue published online: 17 MAR 2009
  2. Article first published online: 10 JUL 2008
  3. Manuscript Accepted: 29 MAY 2008
  4. Manuscript Received: 4 FEB 2008

Funded by

  • National Institute of Health. Grant Number: HL077442

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Keywords:

  • genetics;
  • coronary disease;
  • depression;
  • endothelium

Abstract

Numerous studies suggest that the prevalence of depression is greater among cardiac patients than in the general population. However, little attention has been paid to the possibility of genetic contributions to depressive symptoms in cardiac patients. We conducted a candidate gene study focusing on genes related to inflammation, platelet aggregation, endothelial function and omega-3 fatty acid metabolism as predictors of depressive symptoms among 977 participants with established cardiovascular disease. Results suggested that genetic variation related to endothelial dysfunction is predictive of depressive symptoms and that endothelial dysfunction may be a novel mechanism contributing to depressive symptoms among cardiac patients. © 2008 Wiley-Liss, Inc.

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