Please cite this article as follows: Kas MJH, Kaye WH, Foulds Mathes W, Bulik CM. 2009. Interspecies Genetics of Eating Disorder Traits. Am J Med Genet Part B 150B:318–327.
Interspecies genetics of eating disorder traits†
Version of Record online: 21 JUL 2008
Copyright © 2008 Wiley-Liss, Inc.
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Volume 150B, Issue 3, pages 318–327, 5 April 2009
How to Cite
Kas, M. J.H., Kaye, W. H., Foulds Mathes, W. and Bulik, C. M. (2009), Interspecies genetics of eating disorder traits. Am. J. Med. Genet., 150B: 318–327. doi: 10.1002/ajmg.b.30832
- Issue online: 17 MAR 2009
- Version of Record online: 21 JUL 2008
- Manuscript Accepted: 10 JUN 2008
- Manuscript Received: 1 APR 2008
- The Netherlands Organization for Scientific Research (NWO). Grant Number: 91786327
- National Institute of Health. Grant Number: T32MH076694
- psychiatry, animal model
Family and twin studies have indicated that genetic factors play a role in the development of eating disorders, such as anorexia and bulimia nervosa, but novel views and tools may enhance the identification of neurobiological mechanisms underlying these conditions. Here we propose an integrative genetic approach to reveal novel biological substrates of eating disorder traits analogous in mouse and human. For example, comparable to behavioral hyperactivity that is observed in 40–80% of anorexia nervosa patients, inbred strains of mice with different genetic backgrounds are differentially susceptible to develop behavioral hyperactivity when food restricted. In addition, a list of characteristics that are relevant to eating disorders and approaches to their measurement in humans together with potential analogous rodent models has been generated. Interspecies genetics of neurobehavioral characteristics of eating disorders has the potential to open new roads to identify and functionally test genetic pathways that influence neurocircuits relevant for these heterogeneous psychiatric disorders. © 2008 Wiley-Liss, Inc.