Please cite this article as follows: Kollins SH, Anastopoulos AD, Lachiewicz AM, FitzGerald D, Morrissey-Kane E, Garrett ME, Keatts SL, Ashley-Koch AE. 2008. SNPs in Dopamine D2 Receptor Gene (DRD2) and Norepinephrine Transporter Gene (NET) Are Associated With Continuous Performance Task (CPT) Phenotypes in ADHD Children and Their Families. Am J Med Genet Part B 147B:1580–1588.
SNPs in dopamine D2 receptor gene (DRD2) and norepinephrine transporter gene (NET) are associated with continuous performance task (CPT) phenotypes in ADHD children and their families†
Article first published online: 26 SEP 2008
Copyright © 2008 Wiley-Liss, Inc.
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Special Issue: Special Issue on the Genetics of ADHD Dedicated to the Memory of Richard Todd
Volume 147B, Issue 8, pages 1580–1588, 5 December 2008
How to Cite
Kollins, S.H., Anastopoulos, A.D., Lachiewicz, A.M., FitzGerald, D., Morrissey-Kane, E., Garrett, M.E., Keatts, S.L. and Ashley-Koch, A.E. (2008), SNPs in dopamine D2 receptor gene (DRD2) and norepinephrine transporter gene (NET) are associated with continuous performance task (CPT) phenotypes in ADHD children and their families. Am. J. Med. Genet., 147B: 1580–1588. doi: 10.1002/ajmg.b.30876
- Issue published online: 18 NOV 2008
- Article first published online: 26 SEP 2008
- Manuscript Accepted: 3 SEP 2008
- Manuscript Received: 23 JUL 2008
- National Institutes of Health (NIH). Grant Numbers: 1R01NS049067, ES011961-01A1, K24DA023464
Haplotype-tagging SNP analyses were conducted to identify molecular genetic substrates of quantitative phenotypes derived from performance on a Continuous Performance Task (CPT). Three hundred sixty-four individuals were sampled from 152 families ascertained on the basis of at least one child having ADHD. Probands, their affected and unaffected siblings, and parents were administered a CPT. Four different components of performance were analyzed and tested for association with SNPs from 10 candidate genes involved in monoaminergic function. After correcting for multiple comparisons and controlling for multiple individuals from the same family, significant associations were identified between commission errors and SNPs in the DRD2 gene (rs2075654, rs1079596), and between reaction time variability and a SNP in the NET gene (rs3785155). These findings suggest that commission errors and reaction time variability are excellent candidates as ADHD endophenotypes based on previously published criteria. Results also shed light on the molecular genetic basis of specific processes that may underlie the disorder. © 2008 Wiley-Liss, Inc.