SEARCH

SEARCH BY CITATION

REFERENCES

  • Alexopoulos GS, Schultz SK, Lebowitz BD. 2005. Late-life depression: A model for medical classification. Biol Psychiatry 58(4): 283289.
  • Arai M, Itokawa M, Yamada K, Toyota T, Arai M, Haga S, Ujike H, Sora I, Ikeda K, Yoshikawa T. 2004. Association of neural cell adhesion molecule 1 gene polymorphisms with bipolar affective disorder in Japanese individuals. Biol Psychiatry 55(8): 804810.
  • Arranz MJ, Erdmann J, Kirov G, Rietschel M, Sodhi M, Albus M, Ball D, Maier W, Davies N, Franzek E., et al. 1997. 5-HT2A receptor and bipolar affective disorder: Association studies in affected patients. Neurosci Lett 224(2): 9598.
  • Aston C, Jiang L, Sokolov BP. 2005. Transcriptional profiling reveals evidence for signaling and oligodendroglial abnormalities in the temporal cortex from patients with major depressive disorder. Mol Psychiatry 10(3): 309322.
  • Atz ME, Rollins B, Vawter MP. 2007. NCAM1 association study of bipolar disorder and schizophrenia: Polymorphisms and alternatively spliced isoforms lead to similarities and differences. Psychiatr Genet 17(2): 5567.
  • Badenhop RF, Moses MJ, Scimone A, Mitchell PB, Ewen-White KR, Rosso A, Donald JA, Adams LJ, Schofield PR. 2002. A genome screen of 13 bipolar affective disorder pedigrees provides evidence for susceptibility loci on chromosome 3 as well as chromosomes. 9:13 and 19. Mol Psychiatry 7(8): 851859.
  • Bailer U, Leisch F, Meszaros K, Lenzinger E, Willinger U, Strobl R, Heiden A, Gebhardt C, Doge E, Fuchs K., et al. 2002. Genome scan for susceptibility loci for schizophrenia and bipolar disorder. Biol Psychiatry 52(1): 4052.
  • Baron M. 2001. Genetic linkage and bipolar disorder: A cautionary note. J Affect Disord 67(1–3): 267273.
  • Barr CS, Schwandt ML, Lindell SG, Higley JD, Maestripieri D, Goldman D, Suomi SJ, Heilig M. 2008. Variation at the mu-opioid receptor gene (OPRM1) influences attachment behavior in infant primates. Proc Natl Acad Sci USA 105(13): 52775281.
  • Bauer M, Grof P, Rasgon N, Bschor T, Glenn T, Whybrow PC. 2006. Temporal relation between sleep and mood in patients with bipolar disorder. Bipolar Disord 8(2): 160167.
  • Baum AE, Akula N, Cabanero M, Cardona I, Corona W, Klemens B, Schulze TG, Cichon S, Rietschel M, Nothen MM, Georgi A, Schumacher J, Schwarz M, Abou Jamra R, Hofels S, Propping P, Satagopan J, Detera-Wadleigh SD, Hardy J, McMahon FJ. 2008. A genome-wide association study implicates diacylglycerol kinase eta (DGKH) and several other genes in the etiology of bipolar disorder. Mol Psychiatry 13(2): 197207.
  • Beasley CL, Pennington K, Behan A, Wait R, Dunn MJ, Cotter D. 2006. Proteomic analysis of the anterior cingulate cortex in the major psychiatric disorders: Evidence for disease-associated changes. Proteomics 6(11): 34143425.
  • Beaulieu JM, Marion S, Rodriguiz RM, Medvedev IO, Sotnikova TD, Ghisi V, Wetsel WC, Lefkowitz RJ, Gainetdinov RR, Caron MG. 2008a. A beta-arrestin 2 signaling complex mediates lithium action on behavior. Cell 132(1): 125136.
  • Beaulieu JM, Zhang X, Rodriguiz RM, Sotnikova TD, Cools MJ, Wetsel WC, Gainetdinov RR, Caron MG. 2008b. Role of GSK3 beta in behavioral abnormalities induced by serotonin deficiency. Proc Natl Acad Sci USA 105(4): 13331338.
  • Benedetti F, Serretti A, Colombo C, Lorenzi C, Tubazio V, Smeraldi E. 2004. A glycogen synthase kinase 3-beta promoter gene single nucleotide polymorphism is associated with age at onset and response to total sleep deprivation in bipolar depression. Neurosci Lett 368(2): 123126.
  • Benes FM. 2007. Searching for unique endophenotypes for schizophrenia and bipolar disorder within neural circuits and their molecular regulatory mechanisms. Schizophr Bull 33(4): 932936.
  • Benes FM, Matzilevich D, Burke RE, Walsh J. 2006. The expression of proapoptosis genes is increased in bipolar disorder, but not in schizophrenia. Mol Psychiatry 11(3): 241251.
  • Bertram I, Bernstein HG, Lendeckel U, Bukowska A, Dobrowolny H, Keilhoff G, Kanakis D, Mawrin C, Bielau H, Falkai P., et al. 2007. Immunohistochemical evidence for impaired neuregulin-1 signaling in the prefrontal cortex in schizophrenia and in unipolar depression. Ann NY Acad Sci 1096: 147156.
  • Bezchlibnyk YB, Wang JF, McQueen GM, Young LT. 2001. Gene expression differences in bipolar disorder revealed by cDNA array analysis of post-mortem frontal cortex. J Neurochem 79(4): 826834.
  • Bunney WE, Bunney BG. 2000. Molecular clock genes in man and lower animals: Possible implications for circadian abnormalities in depression. Neuropsychopharmacology 22(4): 335345.
  • Camp NJ, Lowry MR, Richards RL, Plenk AM, Carter C, Hensel CH, Abkevich V, Skolnick MH, Shattuck D, Rowe KG., et al. 2005. Genome-wide linkage analyses of extended Utah pedigrees identifies loci that influence recurrent, early-onset major depression and anxiety disorders. Am J Med Genet B Neuropsychiatr Genet 135(1): 8593.
  • Chagnon YC, Merette C, Bouchard RH, Emond C, Roy MA, Maziade M. 2004. A genome wide linkage study of obesity as secondary effect of antipsychotics in multigenerational families of eastern Quebec affected by psychoses. Mol Psychiatry 9(12): 10671074.
  • Chambers JS, Perrone-Bizzozero NI. 2004. Altered myelination of the hippocampal formation in subjects with schizophrenia and bipolar disorder. Neurochem Res 29(12): 22932302.
  • Chao HM, Kao HT, Porton B. 2008. BDNF Val66Met variant and age of onset in schizophrenia. Am J Med Genet Part B 147B(4): 505506.
  • Cheng R, Juo SH, Loth JE, Nee J, Iossifov I, Blumenthal R, Sharpe L, Kanyas K, Lerer B, Lilliston B., et al. 2006. Genome-wide linkage scan in a large bipolar disorder sample from the National Institute of Mental Health genetics initiative suggests putative loci for bipolar disorder, psychosis, suicide, and panic disorder. Mol Psychiatry 11(3): 252260.
  • Choudary PV, Molnar M, Evans SJ, Tomita H, Li JZ, Vawter MP, Myers RM, Bunney WE Jr, Akil H, Watson SJ., et al. 2005. Altered cortical glutamatergic and GABAergic signal transmission with glial involvement in depression. Proc Natl Acad Sci USA 102(43): 1565315658.
  • Cichon S, Schumacher J, Muller DJ, Hurter M, Windemuth C, Strauch K, Hemmer S, Schulze TG, Schmidt-Wolf G, Albus M., et al. 2001. A genome screen for genes predisposing to bipolar affective disorder detects a new susceptibility locus on. 8q. Hum Mol Genet. 10(25): 2933–2944.
  • Clamp M, Fry B, Kamal M, Xie X, Cuff J, Lin MF, Kellis M, Lindblad-Toh K, Lander ES. 2007. Distinguishing protein-coding and noncoding genes in the human genome. Proc Natl Acad Sci USA 104(49): 1942819433.
  • Coon H, Hoff M, Holik J, Hadley D, Fang N, Reimherr F, Wender P, Byerley W. 1996. Analysis of chromosome 18 DNA markers in multiplex pedigrees with manic depression. Biol Psychiatry 39(8): 689696.
  • Craddock N, Roberts Q, Williams N, McGuffin P, Owen MJ. 1995. Association study of bipolar disorder using a functional polymorphism (Ser311[RIGHTWARDS ARROW]Cys) in the dopamine D2 receptor gene. Psychiatr Genet 5(2): 6365.
  • Curtis D, Kalsi G, Brynjolfsson J, McInnis M, O'Neill J, Smyth C, Moloney E, Murphy P, McQuillin A, Petursson H., et al. 2003. Genome scan of pedigrees multiply affected with bipolar disorder provides further support for the presence of a susceptibility locus on chromosome 12q23-q24, and suggests the presence of additional loci on 1p and. 1q. Psychiatr Genet. 13(2): 77–84.
  • De Luca V, Likhodi O, Van Tol HH, Kennedy JL, Wong AH. 2006. Regulation of alpha7-nicotinic receptor subunit and alpha7-like gene expression in the prefrontal cortex of patients with bipolar disorder and schizophrenia. Acta Psychiatr Scand 114(3): 211215.
  • Degnan JH, Lasky-Su J, Raby BA, Xu M, Molony C, Schadt EE, Lange C. 2008. Genomics and genome-wide association studies: An integrative approach to expression QTL mapping. Genomics 92(3): 129133.
  • Denisenko-Nehrbass NI, Jarvis E, Scharff C, Nottebohm F, Mello CV. 2000. Site-specific retinoic acid production in the brain of adult songbirds. Neuron 27(2): 359370.
  • Detera-Wadleigh SD, Badner JA, Berrettini WH, Yoshikawa T, Goldin LR, Turner G, Rollins DY, Moses T, Sanders AR, Karkera JD., et al. 1999. A high-density genome scan detects evidence for a bipolar-disorder susceptibility locus on 13q32 and other potential loci on 1q32 and 18p11.2. Proc Natl Acad Sci USA 96(10): 56045609.
  • Dick DM, Foroud T, Flury L, Bowman ES, Miller MJ, Rau NL, Moe PR, Samavedy N, El-Mallakh R, Manji H., et al. 2003. Genomewide linkage analyses of bipolar disorder: A new sample of 250 pedigrees from the National Institute of Mental Health Genetics Initiative. Am J Hum Genet 73(1): 107114.
  • Duman RS, Monteggia LM. 2006. A neurotrophic model for stress-related mood disorders. Biol Psychiatry 59(12): 11161127.
  • Etain B, Mathieu F, Rietschel M, Maier W, Albus M, McKeon P, Roche S, Kealey C, Blackwood D, Muir W., et al. 2006. Genome-wide scan for genes involved in bipolar affective disorder in 70 European families ascertained through a bipolar type I early-onset proband: Supportive evidence for linkage at 3p14. Mol Psychiatry 11(7): 685694.
  • Evans SJ, Choudary PV, Neal CR, Li JZ, Vawter MP, Tomita H, Lopez JF, Thompson RC, Meng F, Stead JD., et al. 2004. Dysregulation of the fibroblast growth factor system in major depression. Proc Natl Acad Sci USA 101(43): 1550615511.
  • Evans LM, Akiskal HS, Greenwood TA, Nievergelt CM, Keck PE Jr, McElroy SL, Sadovnick AD, Remick RA, Schork NJ, Kelsoe JR. 2007. Suggestive linkage of a chromosomal locus on 18p11 to cyclothymic temperament in bipolar disorder families. Am J Med Genet B Neuropsychiatr Genet.
  • Ewald H, Wang AG, Vang M, Mors O, Nyegaard M, Kruse TA. 1999. A haplotype-based study of lithium responding patients with bipolar affective disorder on the Faroe Islands. Psychiatr Genet 9(1): 2334.
  • Ewald H, Flint T, Kruse TA, Mors O. 2002. A genome-wide scan shows significant linkage between bipolar disorder and chromosome 12q24.3 and suggestive linkage to chromosomes 1p22-21, 4p16, 6q14-22, 10q26 and 16p13.3. Mol Psychiatry 7(7): 734744.
  • Fallin MD, Lasseter VK, Wolyniec PS, McGrath JA, Nestadt G, Valle D, Liang KY, Pulver AE. 2004. Genomewide linkage scan for bipolar-disorder susceptibility loci among Ashkenazi Jewish families. Am J Hum Genet 75(2): 204219.
  • Fallin MD, Lasseter VK, Avramopoulos D, Nicodemus KK, Wolyniec PS, McGrath JA, Steel G, Nestadt G, Liang KY, Huganir RL., et al. 2005. Bipolar I disorder and schizophrenia: A 440-single-nucleotide polymorphism screen of 64 candidate genes among Ashkenazi Jewish case-parent trios. Am J Hum Genet 77(6): 918936.
  • Fan J, Sklar P. 2008. Genetics of bipolar disorder: Focus on BDNF Val66Met polymorphism. Novartis Found Symp 289: 6072; discussion 72–63, 87–93.
  • Faraone SV, Matise T, Svrakic D, Pepple J, Malaspina D, Suarez B, Hampe C, Zambuto CT, Schmitt K, Meyer J., et al. 1998. Genome scan of European-American schizophrenia pedigrees: Results of the NIMH Genetics Initiative and Millennium Consortium. Am J Med Genet 81(4): 290295.
  • Foroud T, Castelluccio PF, Koller DL, Edenberg HJ, Miller M, Bowman E, Rau NL, Smiley C, Rice JP, Goate A., et al. 2000. Suggestive evidence of a locus on chromosome 10p using the NIMH genetics initiative bipolar affective disorder pedigrees. Am J Med Genet 96(1): 1823.
  • Franken P, Lopez-Molina L, Marcacci L, Schibler U, Tafti M. 2000. The transcription factor DBP affects circadian sleep consolidation and rhythmic EEG activity. J Neurosci 20(2): 617625.
  • Freimer NB, Reus VI, Escamilla MA, McInnes LA, Spesny M, Leon P, Service SK, Smith LB, Silva S, Rojas E., et al. 1996. Genetic mapping using haplotype, association and linkage methods suggests a locus for severe bipolar disorder (BPI) at 18q22-q23. Nat Genet 12(4): 436441.
  • Galter D, Buervenich S, Carmine A, Anvret M, Olson L. 2003. ALDH1 mRNA: Presence in human dopamine neurons and decreases in substantia nigra in Parkinson's disease and in the ventral tegmental area in schizophrenia. Neurobiol Dis 14(3): 637647.
  • Goes FS, Zandi PP, Miao K, McMahon FJ, Steele J, Willour VL, Mackinnon DF, Mondimore FM, Schweizer B, Nurnberger JI Jr., et al. 2007. Mood-incongruent psychotic features in bipolar disorder: Familial aggregation and suggestive linkage to 2p11-q14 and 13q21-33. Am J Psychiatry 164(2): 236247.
  • Green EK, Raybould R, Macgregor S, Gordon-Smith K, Heron J, Hyde S, Grozeva D, Hamshere M, Williams N, Owen MJ., et al. 2005. Operation of the schizophrenia susceptibility gene, neuregulin 1, across traditional diagnostic boundaries to increase risk for bipolar disorder. Arch Gen Psychiatry 62(6): 642648.
  • GWAS. 2007. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447(7145): 661678.
  • Hasler G, Drevets WC, Gould TD, Gottesman II, Manji HK. 2006. Toward constructing an endophenotype strategy for bipolar disorders. Biol Psychiatry 60(2): 93105.
  • Hennah W, Thomson P, McQuillin A, Bass N, Loukola A, Anjorin A, Blackwood D, Curtis D, Deary IJ, Harris SE., et al. 2008. DISC1 association, heterogeneity and interplay in schizophrenia and bipolar disorder. Mol Psychiatry.
  • Hikida T, Jaaro-Peled H, Seshadri S, Oishi K, Hookway C, Kong S, Wu D, Xue R, Andrade M, Tankou S, Mori S, Gallagher M, Ishizuka K, Pletnikov M, Kida S, Sawa A. 2007. Dominant-negative DISC1 transgenic mice display schizophrenia-associated phenotypes detected by measures translatable to humans. Proc Natl Acad Sci USA 104(36): 1450114506.
  • Hishimoto A, Cui H, Mouri K, Nushida H, Ueno Y, Maeda K, Shirakawa O. 2008. A functional polymorphism of the micro-opioid receptor gene is associated with completed suicides. J Neural Transm 115(3): 531536.
  • Hodgkinson CA, Goldman D, Jaeger J, Persaud S, Kane JM, Lipsky RH, Malhotra AK. 2004. Disrupted in schizophrenia 1 (DISC1): Association with schizophrenia, schizoaffective disorder, and bipolar disorder. Am J Hum Genet 75(5): 862872.
  • Hong CJ, Lai IC, Liou LL, Tsai SJ. 2004. Association study of the human partially duplicated alpha7 nicotinic acetylcholine receptor genetic variant with bipolar disorder. Neurosci Lett 355(1–2): 6972.
  • Iga J, Ueno S, Yamauchi K, Numata S, Motoki I, Tayoshi S, Kinouchi S, Ohta K, Song H, Morita K., et al. 2006. Gene expression and association analysis of LIM (PDLIM5) in major depression. Neurosci Lett 400(3): 203207.
  • Ishiguro H, Ohtsuki T, Okubo Y, Kurumaji A, Arinami T. 2001. Association analysis of the pituitary adenyl cyclase activating peptide gene (PACAP) on chromosome 18p11 with schizophrenia and bipolar disorders. J Neural Transm 108(7): 849854.
  • Iwamoto K, Kakiuchi C, Bundo M, Ikeda K, Kato T. 2004. Molecular characterization of bipolar disorder by comparing gene expression profiles of postmortem brains of major mental disorders. Mol Psychiatry 9(4): 406416.
  • Johansson C, Willeit M, Smedh C, Ekholm J, Paunio T, Kieseppa T, Lichtermann D, Praschak-Rieder N, Neumeister A, Nilsson LG, Kasper S, Peltonen L, Adolfsson R, Schalling M, Partonen T. 2003. Circadian clock-related polymorphisms in seasonal affective disorder and their relevance to diurnal preference. Neuropsychopharmacology 28(4): 734739.
  • Jurata LW, Bukhman YV, Charles V, Capriglione F, Bullard J, Lemire AL, Mohammed A, Pham Q, Laeng P, Brockman JA, Altar CA. 2004. Comparison of microarray-based mRNA profiling technologies for identification of psychiatric disease and drug signatures. J Neurosci Methods 138(1–2): 173188.
  • Kalman J, Palotas A, Juhasz A, Rimanoczy A, Hugyecz M, Kovacs Z, Galsi G, Szabo Z, Pakaski M, Feher LZ., et al. 2005. Impact of venlafaxine on gene expression profile in lymphocytes of the elderly with major depression–evolution of antidepressants and the role of the “neuro-immune” system. Neurochem Res 30(11): 14291438.
  • Karege F, Schwald M, El Kouaissi R. 2004. Drug-induced decrease of protein kinase a activity reveals alteration in BDNF expression of bipolar affective disorder. Neuropsychopharmacology 29(4): 805812.
  • Kato T, Iwayama Y, Kakiuchi C, Iwamoto K, Yamada K, Minabe Y, Nakamura K, Mori N, Fujii K, Nanko S., et al. 2005. Gene expression and association analyses of LIM (PDLIM5) in bipolar disorder and schizophrenia. Mol Psychiatry 10(11): 10451055.
  • Kelsoe JR, Niculescu AB III. 2002. Finding genes for bipolar disorder in the functional genomics era: From convergent functional genomics to phenomics and back. CNS Spectr 7(3): 215226.
  • Kelsoe JR, Spence MA, Loetscher E, Foguet M, Sadovnick AD, Remick RA, Flodman P, Khristich J, Mroczkowski-Parker Z, Brown JL., et al. 2001. A genome survey indicates a possible susceptibility locus for bipolar disorder on chromosome 22. Proc Natl Acad Sci USA 98(2): 585590.
  • Kim S, Choi KH, Baykiz AF, Gershenfeld HK. 2007. Suicide candidate genes associated with bipolar disorder and schizophrenia: An exploratory gene expression profiling analysis of post-mortem prefrontal cortex. BMC Genomics 8(1): 413.
  • Kingsmore SF, Lindquist IE, Mudge J, Gessler DD, Beavis WD. 2008. Genome-wide association studies: Progress and potential for drug discovery and development. Nature Rev 7(3): 221230.
  • Klempan TA, Sequeira A, Canetti L, Lalovic A, Ernst C, Ffrench-Mullen J, Turecki G. 2007. Altered expression of genes involved in ATP biosynthesis and GABAergic neurotransmission in the ventral prefrontal cortex of suicides with and without major depression. Mol Psychiatry.
  • Knable MB, Barci BM, Webster MJ, Meador-Woodruff J, Torrey EF. 2004. Molecular abnormalities of the hippocampus in severe psychiatric illness: Postmortem findings from the Stanley Neuropathology Consortium. Mol Psychiatry 9(6): 609620, 544.
  • Lachman HM, Stopkova P, Papolos DF, Pedrosa E, Margolis B, Aghalar MR, Saito T. 2006. Analysis of synapsin III-196 promoter mutation in schizophrenia and bipolar disorder. Neuropsychobiology 53(2): 5762.
  • Lachman HM, Pedrosa E, Petruolo OA, Cockerham M, Papolos A, Novak T, Papolos DF, Stopkova P. 2007. Increase in GSK3beta gene copy number variation in bipolar disorder. Am J Med Genet B Neuropsychiatr Genet 144(3): 259265.
  • Lai IC, Hong CJ, Tsai SJ. 2001. Association study of nicotinic-receptor variants and major depressive disorder. J Affect Disord 66(1): 7982.
  • Lambert D, Middle F, Hamshere ML, Segurado R, Raybould R, Corvin A, Green E, O'Mahony E, Nikolov I, Mulcahy T., et al. 2005. Stage 2 of the Wellcome Trust UK-Irish bipolar affective disorder sibling-pair genome screen: Evidence for linkage on chromosomes 6q16-q21, 4q12-q21, 9p21, 10p14-p12 and 18q22. Mol Psychiatry 10(9): 831841.
  • Le-Niculescu H, Balaraman Y, Patel S, Tan J, Sidhu K, Jerome RE, Edenberg HJ, Kuczenski R, Geyer MA, Nurnberger JI Jr, Faraone SV, Tsuang MT, Niculescu AB. 2007a. Towards understanding the schizophrenia code: An expanded convergent functional genomics approach. Am J Med Genet Part B 144B(2): 129158.
  • Le-Niculescu H, McFarland MJ, Mamidipalli S, Ogden CA, Kuczenski R, Kurian SM, Salomon DR, Tsuang MT, Nurnberger JI Jr, Niculescu AB. 2007b. Convergent functional genomics of bipolar disorder: From animal model pharmacogenomics to human genetics and biomarkers. Neurosci Biobehav Rev 31(6): 897903.
  • Le-Niculescu H, Kurian SM, Yehyawi N, Dike C, Patel SD, Edenberg HJ, Tsuang MT, Salomon DR, Nurnberger JI Jr, Niculescu AB. 2008a. Identifying blood biomarkers for mood disorders using convergent functional genomics. Mol Psychiatry [Epub ahead of print].
  • Le-Niculescu H, McFarland MJ, Ogden CA, Balaraman Y, Patel S, Tan J, Rodd ZA, Paulus M, Geyer MA, Edenberg HJ, Glatt SJ, Faraone SV, Nurnberger JI, Kuczenski R, Tsuang MT, Niculescu AB. 2008b. Phenomic, convergent functional genomic, and biomarker studies in a stress-reactive genetic animal model of bipolar disorder and co-morbid alcoholism. Am J Med Genet Part B 147B(2): 134166.
  • Lenox RH, Gould TD, Manji HK. 2002. Endophenotypes in bipolar disorder. Am J Med Genet 114(4): 391406.
  • Levinson DF, Evgrafov OV, Knowles JA, Potash JB, Weissman MM, Scheftner WA, Depaulo JR Jr, Crowe RR, Murphy-Eberenz K, Marta DH., et al. 2007. Genetics of recurrent early-onset major depression (GenRED): Significant linkage on chromosome 15q25-q26 after fine mapping with single nucleotide polymorphism markers. Am J Psychiatry 164(2): 259264.
  • Li T, Liu X, Sham PC, Aitchison KJ, Cai G, Arranz MJ, Deng H, Liu J, Kirov G, Murray RM., et al. 1999. Association analysis between dopamine receptor genes and bipolar affective disorder. Psychiatry Res 86(3): 193201.
  • Liu J, Juo SH, Dewan A, Grunn A, Tong X, Brito M, Park N, Loth JE, Kanyas K, Lerer B., et al. 2003. Evidence for a putative bipolar disorder locus on 2p13-16 and other potential loci on 4q31, 7q34, 8q13, 9q31, 10q21-24, 13q32, 14q21 and 17q11-12. Mol Psychiatry 8(3): 333342.
  • Liu L, Foroud T, Xuei X, Berrettini W, Byerley W, Coryell W, El-Mallakh R, Gershon E, Kelsoe J, Lawson W., et al. 2008. JI Evidence of association between brain-derived neurotrophic factor (BDNF) gene and bipolar disorder. Psychiatric Genetics (in press).
  • Luo X, Zuo L, Kranzler H, Zhang H, Wang S, Gelernter J. 2008. Multiple OPR genes influence personality traits in substance dependent and healthy subjects in two American populations. Am J Med Genet B Neuropsychiatr Genet 147B(7): 10281039.
  • Macgregor S, Visscher PM, Knott SA, Thomson P, Porteous DJ, Millar JK, Devon RS, Blackwood D, Muir WJ. 2004. A genome scan and follow-up study identify a bipolar disorder susceptibility locus on chromosome 1q42. Mol Psychiatry 9(12): 10831090.
  • Maeda K, Nwulia E, Chang J, Balkissoon R, Ishizuka K, Chen H, Zandi P, McInnis MG, Sawa A. 2006. Differential expression of disrupted-in-schizophrenia (DISC1) in bipolar disorder. Biol Psychiatry 60(9): 929935.
  • Magnusson A, Partonen T. 2005. The diagnosis, symptomatology, and epidemiology of seasonal affective disorder. CNS Spectr 10(8): 625634, quiz 621–614.
  • Mansour HA, Wood J, Logue T, Chowdari KV, Dayal M, Kupfer DJ, Monk TH, Devlin B, Nimgaonkar VL. 2006. Association study of eight circadian genes with bipolar I disorder, schizoaffective disorder and schizophrenia. Genes Brain Behav 5(2): 150157.
  • Massat I, Souery D, Del-Favero J, Van Gestel S, Serretti A, Macciardi F, Smeraldi E, Kaneva R, Adolfsson R, Nylander PO., et al. 2002. Positive association of dopamine D2 receptor polymorphism with bipolar affective disorder in a European Multicenter Association Study of affective disorders. Am J Med Genet 114(2): 177185.
  • Matigian N, Windus L, Smith H, Filippich C, Pantelis C, McGrath J, Mowry B, Hayward N. 2007. Expression profiling in monozygotic twins discordant for bipolar disorder reveals dysregulation of the WNT signalling pathway. Mol Psychiatry 12(9): 815825.
  • Maziade M, Roy MA, Chagnon YC, Cliche D, Fournier JP, Montgrain N, Dion C, Lavallee JC, Garneau Y, Gingras N., et al. 2005. Shared and specific susceptibility loci for schizophrenia and bipolar disorder: A dense genome scan in Eastern Quebec families. Mol Psychiatry 10(5): 486499.
  • McClung CA. 2007. Circadian genes, rhythms and the biology of mood disorders. Pharmacol Ther 114(2): 222232.
  • McInnes LA, Escamilla MA, Service SK, Reus VI, Leon P, Silva S, Rojas E, Spesny M, Baharloo S, Blankenship K., et al. 1996. A complete genome screen for genes predisposing to severe bipolar disorder in two Costa Rican pedigrees. Proc Natl Acad Sci USA 93(23): 1306013065.
  • McInnis MG, Dick DM, Willour VL, Avramopoulos D, MacKinnon DF, Simpson SG, Potash JB, Edenberg HJ, Bowman ES, McMahon FJ., et al. 2003. Genome-wide scan and conditional analysis in bipolar disorder: Evidence for genomic interaction in the National Institute of Mental Health genetics initiative bipolar pedigrees. Biol Psychiatry 54(11): 12651273.
  • McPherson R, Pertsemlidis A, Kavaslar N, Stewart A, Roberts R, Cox DR, Hinds DA, Pennacchio LA, Tybjaerg-Hansen A, Folsom AR, Boerwinkle E, Hobbs HH, Cohen JC. 2007. A common allele on chromosome 9 associated with coronary heart disease. Science 316(5830): 14881491.
  • McQueen MB, Devlin B, Faraone SV, Nimgaonkar VL, Sklar P, Smoller JW, Abou Jamra R, Albus M, Bacanu SA, Baron M., et al. 2005. Combined analysis from eleven linkage studies of bipolar disorder provides strong evidence of susceptibility Loci on chromosomes 6q and 8q. Am J Hum Genet 77(4): 582595.
  • Middleton FA, Pato CN, Gentile KL, McGann L, Brown AM, Trauzzi M, Diab H, Morley CP, Medeiros H, Macedo A., et al. 2005. Gene expression analysis of peripheral blood leukocytes from discordant sib-pairs with schizophrenia and bipolar disorder reveals points of convergence between genetic and functional genomic approaches. Am J Med Genet B Neuropsychiatr Genet 136(1): 1225.
  • Millar JK, Mackie S, Clapcote SJ, Murdoch H, Pickard BS, Christie S, Muir WJ, Blackwood DH, Roder JC, Houslay MD., et al. 2007. Disrupted in schizophrenia 1 and phosphodiesterase 4B: Towards an understanding of psychiatric illness. J Physiol 584(Pt 2): 401405.
  • Moore S, Montane-Jaime K, Shafe S, Joseph R, Crooks H, Carr LG, Ehlers CL. 2007. Association of ALDH1 promoter polymorphisms with alcohol-related phenotypes in Trinidad and Tobago. J Stud Alcohol Drugs 68(2): 192196.
  • Morissette J, Villeneuve A, Bordeleau L, Rochette D, Laberge C, Gagne B, Laprise C, Bouchard G, Plante M, Gobeil L, Shink E, Weissenbach J, Barden N. 1999. Genome-wide search for linkage of bipolar affective disorders in a very large pedigree derived from a homogeneous population in quebec points to a locus of major effect on chromosome 12q23-q24. Am J Med Genet 88(5): 567587.
  • Nakatani N, Hattori E, Ohnishi T, Dean B, Iwayama Y, Matsumoto I, Kato T, Osumi N, Higuchi T, Niwa S, Yoshikawa T. 2006. Genome-wide expression analysis detects eight genes with robust alterations specific to bipolar I disorder: Relevance to neuronal network perturbation. Hum Mol Genet 15(12): 19491962.
  • Neves-Pereira M, Mundo E, Muglia P, King N, Macciardi F, Kennedy JL. 2002. The brain-derived neurotrophic factor gene confers susceptibility to bipolar disorder: Evidence from a family-based association study. Am J Hum Genet 71(3): 651655.
  • Niculescu AB. 2005. Genomic studies of mood disorders—The brain as a muscle? Genome Biol 6(4): 215.
  • Niculescu AB III, Akiskal HS. 2001a. Proposed endophenotypes of dysthymia: Evolutionary, clinical and pharmacogenomic considerations. Mol Psychiatry 6(4): 363366.
  • Niculescu AB, Akiskal HS. 2001b. Sex hormones, Darwinism, and depression. Arch Gen Psychiatry 58(11): 10831084, author reply 1085–1086.
  • Niculescu AB III, Kelsoe JR. 2001. Convergent functional genomics: Application to bipolar disorder. Ann Med 33(4): 263271.
  • Niculescu A, Segal D, Kuczenski R, Barrett T, Hauger R, Kelsoe J. 2000a. Identifying a series of candidate genes for mania and psychosis: A convergent functional genomics approach. Physiol Genomics 4(1): 8391.
  • Niculescu AB III, Segal DS, Kuczenski R, Barrett T, Hauger RL, Kelsoe JR. 2000b. Identifying a series of candidate genes for mania and psychosis: A convergent functional genomics approach. Physiol Genomics 4(1): 8391.
  • Niculescu AB, Lulow LL, Ogden CA, Le-Niculescu H, Salomon DR, Schork NJ, Caligiuri MP, Lohr JB. 2006. PhenoChipping of psychotic disorders: A novel approach for deconstructing and quantitating psychiatric phenotypes. Am J Med Genet Part B 141B(6): 653662.
  • Nievergelt CM, Kripke DF, Barrett TB, Burg E, Remick RA, Sadovnick AD, McElroy SL, Keck PE Jr, Schork NJ, Kelsoe JR. 2006. Suggestive evidence for association of the circadian genes PERIOD3 and ARNTL with bipolar disorder. Am J Med Genet Part B 141B(3): 234241.
  • Nishiguchi N, Breen G, Russ C, St Clair D, Collier D. 2006. Association analysis of the glycogen synthase kinase-3beta gene in bipolar disorder. Neurosci Lett 394(3): 243245.
  • Novak G, Seeman P, Tallerico T. 2006. Increased expression of calcium/calmodulin-dependent protein kinase IIbeta in frontal cortex in schizophrenia and depression. Synapse 59(1): 6168.
  • Nunes PV, Forlenza OV, Gattaz WF. 2007. Lithium and risk for Alzheimer's disease in elderly patients with bipolar disorder. Br J Psychiatry 190: 359360.
  • Nurnberger JI Jr, Foroud T, Flury L, Su J, Meyer ET, Hu K, Crowe R, Edenberg H, Goate A, Bierut L., et al. 2001. Evidence for a locus on chromosome 1 that influences vulnerability to alcoholism and affective disorder. Am J Psychiatry 158(5): 718724.
  • Oertel B, Lotsch J. 2008. Genetic mutations that prevent pain: Implications for future pain medication. Pharmacogenomics 9(2): 179194.
  • Ogden CA, Rich ME, Schork NJ, Paulus MP, Geyer MA, Lohr JB, Kuczenski R, Niculescu AB. 2004. Candidate genes, pathways and mechanisms for bipolar (manic-depressive) and related disorders: An expanded convergent functional genomics approach. Mol Psychiatry 9(11): 10071029.
  • Oh ES, Savonenko AV, King JF, Fangmark Tucker SM, Rudow GL, Xu G, Borchelt DR, Troncoso JC. 2008. Amyloid precursor protein increases cortical neuron size in transgenic mice. Neurobiol Aging [Epub ahead of print].
  • Ohnishi T, Yamada K, Ohba H, Iwayama Y, Toyota T, Hattori E, Inada T, Kunugi H, Tatsumi M, Ozaki N., et al. 2007. A promoter haplotype of the inositol monophosphatase 2 gene (IMPA2) at 18p11.2 confers a possible risk for bipolar disorder by enhancing transcription. Neuropsychopharmacology 32(8): 17271737.
  • Park N, Juo SH, Cheng R, Liu J, Loth JE, Lilliston B, Nee J, Grunn A, Kanyas K, Lerer B., et al. 2004. Linkage analysis of psychosis in bipolar pedigrees suggests novel putative loci for bipolar disorder and shared susceptibility with schizophrenia. Mol Psychiatry 9(12): 10911099.
  • Partonen T, Treutlein J, Alpman A, Frank J, Johansson C, Depner M, Aron L, Rietschel M, Wellek S, Soronen P, Paunio T, Koch A, Chen P, Lathrop M, Adolfsson R, Persson ML, Kasper S, Schalling M, Peltonen L, Schumann G. 2007. Three circadian clock genes Per2, Arntl, and Npas2 contribute to winter depression. Ann Med 39(3): 229238.
  • Pennington K, Beasley CL, Dicker P, Fagan A, English J, Pariante CM, Wait R, Dunn MJ, Cotter DR. 2007. Prominent synaptic and metabolic abnormalities revealed by proteomic analysis of the dorsolateral prefrontal cortex in schizophrenia and bipolar disorder. Mol Psychiatry.
  • Peroutka SJ, Price SC, Wilhoit TL, Jones KW. 1998. Comorbid migraine with aura, anxiety, and depression is associated with dopamine D2 receptor (DRD2) NcoI alleles. Mol Med 4(1): 1421.
  • Pezawas L, Meyer-Lindenberg A, Goldman AL, Verchinski BA, Chen G, Kolachana BS, Egan MF, Mattay VS, Hariri AR, Weinberger DR. 2008. Evidence of biologic epistasis between BDNF and SLC6A4 and implications for depression. Mol Psychiatry 13(7): 654, 709–616.
  • Pletnikov MV, Xu Y, Ovanesov MV, Kamiya A, Sawa A, Ross CA. 2007. PC12 cell model of inducible expression of mutant DISC1: New evidence for a dominant-negative mechanism of abnormal neuronal differentiation. Neurosci Res 58(3): 234244.
  • Potash JB, Zandi PP, Willour VL, Lan TH, Huo Y, Avramopoulos D, Shugart YY, MacKinnon DF, Simpson SG, McMahon FJ, DePaulo JR Jr, McInnis MG. 2003. Suggestive linkage to chromosomal regions 13q31 and 22q12 in families with psychotic bipolar disorder. Am J Psychiatry 160(4): 680686.
  • Quiroz JA, Gray NA, Kato T, Manji HK. 2008. Mitochondrially mediated plasticity in the pathophysiology and treatment of bipolar disorder. Neuropsychopharmacology 33(11): 25512565.
  • Radhakrishna U, Senol S, Herken H, Gucuyener K, Gehrig C, Blouin JL, Akarsu NA, Antonarakis SE. 2001. An apparently dominant bipolar affective disorder (BPAD) locus on chromosome 20p11.2-q11.2 in a large Turkish pedigree. Eur J Hum Genet 9(1): 3944.
  • Ranade SS, Mansour H, Wood J, Chowdari KV, Brar LK, Kupfer DJ, Nimgaonkar VL. 2003. Linkage and association between serotonin 2A receptor gene polymorphisms and bipolar I disorder. Am J Med Genet B Neuropsychiatr Genet 121(1): 2834.
  • Rice JP, Goate A, Williams JT, Bierut L, Dorr D, Wu W, Shears S, Gopalakrishnan G, Edenberg HJ, Foroud T., et al. 1997. Initial genome scan of the NIMH genetics initiative bipolar pedigrees: Chromosomes 1, 6, 8, 10, and 12. Am J Med Genet 74(3): 247253.
  • Rice TK, Schork NJ, Rao DC. 2008. Methods for handling multiple testing. Adv Genet 60: 293308.
  • Ripperger JA, Schibler U. 2006. Rhythmic CLOCK-BMAL1 binding to multiple E-box motifs drives circadian Dbp transcription and chromatin transitions. Nat Genet 38(3): 369374.
  • Rodd ZA, Bertsch BA, Strother WN, Le-Niculescu H, Balaraman Y, Hayden E, Jerome RE, Lumeng L, Nurnberger JI Jr, Edenberg HJ, McBride WJ, Niculescu AB. 2007. Candidate genes, pathways and mechanisms for alcoholism: An expanded convergent functional genomics approach. Pharmacogenomics J 7(4): 222256.
  • Rohn TT, Vyas V, Hernandez-Estrada T, Nichol KE, Christie LA, Head E. 2008. Lack of pathology in a triple transgenic mouse model of Alzheimer's disease after overexpression of the anti-apoptotic protein Bcl-2. J Neurosci 28(12): 30513059.
  • Ryan MM, Lockstone HE, Huffaker SJ, Wayland MT, Webster MJ, Bahn S. 2006. Gene expression analysis of bipolar disorder reveals downregulation of the ubiquitin cycle and alterations in synaptic genes. Mol Psychiatry 11(10): 965978.
  • Schosser A, Fuchs K, Leisch F, Bailer U, Meszaros K, Lenzinger E, Willinger U, Strobl R, Heiden A, Gebhardt C., et al. 2004. Possible linkage of schizophrenia and bipolar affective disorder to chromosome 3q29; a follow-up. J Psychiatr Res 38(3): 357364.
  • Schulze TG, Chen YS, Badner JA, McInnis MG, DePaulo JR Jr, McMahon FJ. 2003. Additional, physically ordered markers increase linkage signal for bipolar disorder on chromosome 18q22. Biol Psychiatry 53(3): 239243.
  • Schulze TG, Buervenich S, Badner JA, Steele CJ, Detera-Wadleigh SD, Dick D, Foroud T, Cox NJ, MacKinnon DF, Potash JB., et al. 2004. Loci on chromosomes 6q and 6p interact to increase susceptibility to bipolar affective disorder in the national institute of mental health genetics initiative pedigrees. Biol Psychiatry 56(1): 1823.
  • Schumacher J, Jamra RA, Becker T, Ohlraun S, Klopp N, Binder EB, Schulze TG, Deschner M, Schmal C, Hofels S., et al. 2005. Evidence for a relationship between genetic variants at the brain-derived neurotrophic factor (BDNF) locus and major depression. Biol Psychiatry 58(4): 307314.
  • Segurado R, Detera-Wadleigh SD, Levinson DF, Lewis CM, Gill M, Nurnberger JI Jr, Craddock N, DePaulo JR, Baron M, Gershon ES., et al. 2003. Genome scan meta-analysis of schizophrenia and bipolar disorder, part III: Bipolar disorder. Am J Hum Genet 73(1): 4962.
  • Sen S, Duman R, Sanacora G. 2008. Serum brain-derived neurotrophic factor, depression, and antidepressant medications: Meta-analyses and implications. Biol Psychiatry 64(6): 527532.
  • Sequeira A, Klempan T, Canetti L, ffrench-Mullen J, Benkelfat C, Rouleau GA, Turecki G. 2007. Patterns of gene expression in the limbic system of suicides with and without major depression. Mol Psychiatry 12(7): 640655.
  • Serretti A, Lattuada E, Lorenzi C, Lilli R, Smeraldi E. 2000. Dopamine receptor D2 Ser/Cys 311 variant is associated with delusion and disorganization symptomatology in major psychoses. Mol Psychiatry 5(3): 270274.
  • Shi J, Wittke-Thompson JK, Badner JA, Hattori E, Potash JB, Willour VL, McMahon FJ, Gershon ES, Liu C. 2008. Clock genes may influence bipolar disorder susceptibility and dysfunctional circadian rhythm. Am J Med Genet Part B Neuropsychiatr Genet 147B(7): 10471055.
  • Sjoholt G, Ebstein RP, Lie RT, Berle JO, Mallet J, Deleuze JF, Levinson DF, Laurent C, Mujahed M, Bannoura I., et al. 2004. Examination of IMPA1 and IMPA2 genes in manic-depressive patients: Association between IMPA2 promoter polymorphisms and bipolar disorder. Mol Psychiatry 9(6): 621629.
  • Sklar P, Gabriel SB, McInnis MG, Bennett P, Lim YM, Tsan G, Schaffner S, Kirov G, Jones I, Owen M., et al. 2002. Family-based association study of 76 candidate genes in bipolar disorder: BDNF is a potential risk locus. Brain-derived neutrophic factor. Mol Psychiatry 7(6): 579593.
  • Sklar P, Pato MT, Kirby A, Petryshen TL, Medeiros H, Carvalho C, Macedo A, Dourado A, Coelho I, Valente J., et al. 2004. Genome-wide scan in Portuguese Island families identifies 5q31-5q35 as a susceptibility locus for schizophrenia and psychosis. Mol Psychiatry 9(2): 213218.
  • Sklar P, Smoller JW, Fan J, Ferreira MAR, Perlis RH, Chambert K, Nimgaonkar VL, McQueen MB, Faraone SV, Kirby A, de Bakker PIW, Ogdie MN, Thase ME, Sachs GS, Todd-Brown K, Gabriel SB, Sougnez C, Gates C, Blumenstiel B, Defelice M, Ardlie KG, Franklin J, Muir WJ, McGhee KA, MacIntyre DJ, McLean A, VanBeck M, McQuillin A, Bass NJ, Robinson M, Lawrence J, Anjorin A, Curtis D, Scolnick EM, Daly MJ, Blackwood DH, Gurling HM, Purcell SM. 2008. Whole-genome association study of bipolar disorder. Mol Psychiatry 13(6): 558569.
  • Sokolov BP, Polesskaya OO, Uhl GR. 2003. Mouse brain gene expression changes after acute and chronic amphetamine. J Neurochem 84(2): 244252.
  • Stumpf MP, Thorne T, de Silva E, Stewart R, An HJ, Lappe M, Wiuf C. 2008. Estimating the size of the human interactome. Proc Natl Acad Sci USA 105(19): 69596964.
  • Sun X, Wang JF, Tseng M, Young LT. 2006. Downregulation in components of the mitochondrial electron transport chain in the postmortem frontal cortex of subjects with bipolar disorder. J Psychiatry Neurosci 31(3): 189196.
  • Sun J, Kuo PH, Riley BP, Kendler KS, Zhao Z. 2008a. Candidate genes for schizophrenia: A survey of association studies and gene ranking. Am J Med Genet Part B Neuropsychiatr Genet 147B(7): 11731181.
  • Sun X, Steffens DC, Au R, Folstein M, Summergrad P, Yee J, Rosenberg I, Mwamburi DM, Qiu WQ. 2008b. Amyloid-associated depression: A prodromal depression of Alzheimer disease? Arch Gen Psychiatry 65(5): 542550.
  • Szczepankiewicz A, Rybakowski JK, Suwalska A, Skibinska M, Leszczynska-Rodziewicz A, Dmitrzak-Weglarz M, Czerski PM, Hauser J. 2006. Association study of the glycogen synthase kinase-3beta gene polymorphism with prophylactic lithium response in bipolar patients. World J Biol Psychiatry 7(3): 158161.
  • Tan HY, Callicott JH, Weinberger DR. 2008. Intermediate phenotypes in schizophrenia genetics redux: Is it a no brainer? Mol Psychiatry 13(3): 233238.
  • Thomson PA, Christoforou A, Morris SW, Adie E, Pickard BS, Porteous DJ, Muir WJ, Blackwood DH, Evans KL. 2007. Association of Neuregulin 1 with schizophrenia and bipolar disorder in a second cohort from the Scottish population. Mol Psychiatry 12(1): 94104.
  • Tkachev D, Mimmack ML, Ryan MM, Wayland M, Freeman T, Jones PB, Starkey M, Webster MJ, Yolken RH, Bahn S. 2003. Oligodendrocyte dysfunction in schizophrenia and bipolar disorder. Lancet 362(9386): 798805.
  • Tochigi M, Iwamoto K, Bundo M, Sasaki T, Kato N, Kato T. 2008. Gene expression profiling of major depression and suicide in the prefrontal cortex of postmortem brains. Neurosci Res 60(2): 184191.
  • Torrey EF, Barci BM, Webster MJ, Bartko JJ, Meador-Woodruff JH, Knable MB. 2005. Neurochemical markers for schizophrenia, bipolar disorder, and major depression in postmortem brains. Biol Psychiatry 57(3): 252260.
  • Turecki G, Grof P, Grof E, D'Souza V, Lebuis L, Marineau C, Cavazzoni P, Duffy A, Betard C, Zvolsky P., et al. 2001. Mapping susceptibility genes for bipolar disorder: A pharmacogenetic approach based on excellent response to lithium. Mol Psychiatry 6(5): 570578.
  • van der Veen DR, Minh NL, Gos P, Arneric M, Gerkema MP, Schibler U. 2006. Impact of behavior on central and peripheral circadian clocks in the common vole Microtus arvalis, a mammal with ultradian rhythms. Proc Natl Acad Sci USA 103(9): 33933398.
  • van West D, Van Den Eede F, Del-Favero J, Souery D, Norrback KF, Van Duijn C, Sluijs S, Adolfsson R, Mendlewicz J, Deboutte D., et al. 2006. Glucocorticoid receptor gene-based SNP analysis in patients with recurrent major depression. Neuropsychopharmacology 31(3): 620627.
  • Vawter MP, Thatcher L, Usen N, Hyde TM, Kleinman JE, Freed WJ. 2002. Reduction of synapsin in the hippocampus of patients with bipolar disorder and schizophrenia. Mol Psychiatry 7(6): 571578.
  • Vawter MP, Tomita H, Meng F, Bolstad B, Li J, Evans S, Choudary P, Atz M, Shao L, Neal C., et al. 2006. Mitochondrial-related gene expression changes are sensitive to agonal-pH state: Implications for brain disorders. Mol Psychiatry.
  • Wager-Smith K, Kay SA. 2000. Circadian rhythm genetics: From flies to mice to humans. Nature Genet 26(1): 2327.
  • Walsh T, McClellan JM, McCarthy SE, Addington AM, Pierce SB, Cooper GM, Nord AS, Kusenda M, Malhotra D, Bhandari A, Stray SM, Rippey CF, Roccanova P, Makarov V, Lakshmi B, Findling RL, Sikich L, Stromberg T, Merriman B, Gogtay N, Butler P, Eckstrand K, Noory L, Gochman P, Long R, Chen Z, Davis S, Baker C, Eichler EE, Meltzer PS, Nelson SF, Singleton AB, Lee MK, Rapoport JL, King MC, Sebat J. 2008. Rare structural variants disrupt multiple genes in neurodevelopmental pathways in schizophrenia. Science 320(5875): 539543.
  • Walss-Bass C, Raventos H, Montero AP, Armas R, Dassori A, Contreras S, Liu W, Medina R, Levinson DF, Pereira M., et al. 2006. Association analyses of the neuregulin 1 gene with schizophrenia and manic psychosis in a Hispanic population. Acta Psychiatr Scand 113(4): 314321.
  • Willer CJ, Sanna S, Jackson AU, Scuteri A, Bonnycastle LL, Clarke R, Heath SC, Timpson NJ, Najjar SS, Stringham HM, Strait J, Duren WL, Maschio A, Busonero F, Mulas A, Albai G, Swift AJ, Morken MA, Narisu N, Bennett D, Parish S, Shen H, Galan P, Meneton P, Hercberg S, Zelenika D, Chen WM, Li Y, Scott LJ, Scheet PA, Sundvall J, Watanabe RM, Nagaraja R, Ebrahim S, Lawlor DA, Ben-Shlomo Y, Davey-Smith G, Shuldiner AR, Collins R, Bergman RN, Uda M, Tuomilehto J, Cao A, Collins FS, Lakatta E, Lathrop GM, Boehnke M, Schlessinger D, Mohlke KL, Abecasis GR. 2008. Newly identified loci that influence lipid concentrations and risk of coronary artery disease. Nature Genet 40(2): 161169.
  • Wirz-Justice A. 2006. Biological rhythm disturbances in mood disorders. Int Clin Psychopharmacol 21(Suppl 1): S11S15.
  • Wirz-Justice A, Terman M, Oren DA, Goodwin FK, Kripke DF, Whybrow PC, Wisner KL, Wu JC, Lam RW, Berger M, Danilenko KV, Kasper S, Smeraldi E, Takahashi K, Thompson C, van den Hoofdakker RH. 2004. Brightening depression. Science 303(5657): 467469.
  • Wisor JP, O'Hara BF, Terao A, Selby CP, Kilduff TS, Sancar A, Edgar DM, Franken P. 2002. A role for cryptochromes in sleep regulation. BMC Neurosci 3: 20.
  • Xing G, Russell S, Hough C, O'Grady J, Zhang L, Yang S, Zhang LX, Post R. 2002. Decreased prefrontal CaMKII alpha mRNA in bipolar illness. Neuroreport 13(4): 501505.
  • Yang S, Van Dongen HP, Wang K, Berrettini W, Bucan M. 2008. Assessment of circadian function in fibroblasts of patients with bipolar disorder. Mol Psychiatry [Epub ahead of print].
  • Yoon IS, Li PP, Siu KP, Kennedy JL, Cooke RG, Parikh SV, Warsh JJ. 2001. Altered IMPA2 gene expression and calcium homeostasis in bipolar disorder. Mol Psychiatry 6(6): 678683.
  • Zeggini E, Weedon MN, Lindgren CM, Frayling TM, Elliott KS, Lango H, Timpson NJ, Perry JR, Rayner NW, Freathy RM, Barrett JC, Shields B, Morris AP, Ellard S, Groves CJ, Harries LW, Marchini JL, Owen KR, Knight B, Cardon LR, Walker M, Hitman GA, Morris AD, Doney AS, McCarthy MI, Hattersley AT. 2007. Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science (New York, NY) 316(5829): 13361341.
  • Zeggini E, Scott LJ, Saxena R, Voight BF, Marchini JL, Hu T, de Bakker PI, Abecasis GR, Almgren P, Andersen G, Ardlie K, Bostrom KB, Bergman RN, Bonnycastle LL, Borch-Johnsen K, Burtt NP, Chen H, Chines PS, Daly MJ, Deodhar P, Ding CJ, Doney AS, Duren WL, Elliott KS, Erdos MR, Frayling TM, Freathy RM, Gianniny L, Grallert H, Grarup N, Groves CJ, Guiducci C, Hansen T, Herder C, Hitman GA, Hughes TE, Isomaa B, Jackson AU, Jorgensen T, Kong A, Kubalanza K, Kuruvilla FG, Kuusisto J, Langenberg C, Lango H, Lauritzen T, Li Y, Lindgren CM, Lyssenko V, Marvelle AF, Meisinger C, Midthjell K, Mohlke KL, Morken MA, Morris AD, Narisu N, Nilsson P, Owen KR, Palmer CN, Payne F, Perry JR, Pettersen E, Platou C, Prokopenko I, Qi L, Qin L, Rayner NW, Rees M, Roix JJ, Sandbaek A, Shields B, Sjogren M, Steinthorsdottir V, Stringham HM, Swift AJ, Thorleifsson G, Thorsteinsdottir U, Timpson NJ, Tuomi T, Tuomilehto J, Walker M, Watanabe RM, Weedon MN, Willer CJ, Illig T, Hveem K, Hu FB, Laakso M, Stefansson K, Pedersen O, Wareham NJ, Barroso I, Hattersley AT, Collins FS, Groop L, McCarthy MI, Boehnke M, Altshuler D. 2008. Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nature Genet 40(5): 638645.
  • Zubenko GS, Hughes HB, Stiffler JS, Zubenko WN, Kaplan BB. 2002. Genome survey for susceptibility loci for recurrent, early-onset major depression: Results at 10cM resolution. Am J Med Genet 114(4): 413422.
  • Zubenko GS, Maher B, Hughes HB 3rd, Zubenko WN, Stiffler JS, Kaplan BB, Marazita ML. 2003. Genome-wide linkage survey for genetic loci that influence the development of depressive disorders in families with recurrent, early-onset, major depression. Am J Med Genet B Neuropsychiatr Genet 123(1): 118.