Research Article

Association of the dystrobrevin binding protein 1 gene (DTNBP1) in a bipolar case–control study (BACCS)†

  1. Darya Gaysina1,*,
  2. Sarah Cohen-Woods1,
  3. Philip C. Chow1,
  4. Livia Martucci1,
  5. Alexandra Schosser1,2,
  6. Harriet A. Ball1,
  7. Federica Tozzi3,4,
  8. Julia Perry3,4,
  9. Pierandrea Muglia3,4,
  10. Ian W. Craig1,
  11. Peter McGuffin1,
  12. Anne Farmer1

Article first published online: 16 DEC 2008

DOI: 10.1002/ajmg.b.30906

Issue

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

Volume 150B, Issue 6, pages 836–844, 5 September 2009

Additional Information

How to Cite

Gaysina, D., Cohen-Woods, S., Chow, P. C., Martucci, L., Schosser, A., Ball, H. A., Tozzi, F., Perry, J., Muglia, P., Craig, I. W., McGuffin, P. and Farmer, A. (2009), Association of the dystrobrevin binding protein 1 gene (DTNBP1) in a bipolar case–control study (BACCS). American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 150B: 836–844. doi: 10.1002/ajmg.b.30906

Author Information

  1. 1

    MRC SGDP Centre, Institute of Psychiatry, King's College London, De Crespigny Park, London, UK

  2. 2

    Division of Biological Psychiatry, Department of Psychiatry and Psychotherapy, Medical University Vienna, Vienna, Austria

  3. 3

    GSK Research & Development, Medical Genetics, Clinical Pharmacology and Discovery Medicine, Verona, Italy

  4. 4

    GSK Research & Development, Medical Genetics, Clinical Pharmacology and Discovery Medicine, Middlesex, UK

*MRC SGDP Centre, Institute of Psychiatry, King's College London, P.O. Box P080, De Crespigny Park, London SE5 8AF, UK.

  1. †

    Please cite this article as follows: Gaysina D, Cohen-Woods S, Chow PC, Martucci L, Schosser A, Ball HA, Tozzi F, Perry J, Muglia P, Craig IW, McGuffin P, Farmer A. 2009. Association of the Dystrobrevin Binding Protein 1 Gene (DTNBP1) in a Bipolar Case–Control Study (BACCS). Am J Med Genet Part B 150B:836–844.

Publication History

  1. Issue published online: 20 AUG 2009
  2. Article first published online: 16 DEC 2008
  3. Manuscript Accepted: 31 OCT 2008
  4. Manuscript Received: 18 APR 2008

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Keywords:

  • dysbindin;
  • affective disorder;
  • association;
  • psychosis;
  • haplotype

Abstract

Recent studies suggest a degree of overlap in genetic susceptibility across the traditional categories of schizophrenia and bipolar disorder. There is some evidence for an association of the dystrobrevin binding protein 1 gene (DTNBP1) with schizophrenia, and, thus, this gene has also become a focus of further investigation in bipolar disorder (BD). The aim of our study is to explore the association of DTNBP1 with BD and with a sub phenotype, presence/absence of psychotic symptoms, in a sample of 515 patients with BD (ICD10/DSMIV) and 1,316 ethnically matched control subjects recruited from the UK. Seven DTNBP1 SNPs: rs2743852 (SNP C), rs760761 (P1320), rs1011313 (P1325), rs3213207 (P1635), rs2619539 (P1655), rs16876571 and rs17470454 were investigated using the SNPlex genotyping system and 1 SNP (rs2619522) genotypes were imputed. Association analyses were conducted in a sample of 452 cases and 956 controls. We found significant differences in genotypic and allelic frequencies of rs3213207 and rs760761 of DTNBP1 between bipolar patients and controls. We also showed a global haplotypic association and an association of a particular haplotype with BD. Our results are consistent with previous studies in term of a general association between DTNBP1 and bipolar disorder and provide additional evidence that a portion of the genotypic overlap between schizophrenia and bipolar affective disorder is attributable to this gene. © 2008 Wiley-Liss, Inc.

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