Get access

The DRD3 rs6280 polymorphism and prevalence of tardive dyskinesia: A meta-analysis

Authors

  • Huei-Ting Tsai,

    Corresponding author
    1. Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
    2. National Cancer Institute, National Institute of Health, Rockville, Maryland
    • National Cancer Institute, National Institute of Health, DHHS, 6120 Executive Blvd, EPS 7016, Rockville, MD 20852.
    Search for more papers by this author
  • Kari E. North,

    1. Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
    2. Carolina Center for Genome Science, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
    Search for more papers by this author
  • Suzanne L. West,

    1. Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
    2. RTI International Health, Social, and Economics Research, Research Triangle Park, North Carolina
    Search for more papers by this author
  • Charles Poole

    1. Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
    Search for more papers by this author

  • How to Cite this Article: Tsai HT, North KE, West SL, Poole C. 2010. The DRD3 rs6280 Polymorphism and Prevalence of Tardive Dyskinesia: A Meta-Analysis. Am J Med Genet Part B 153B:57–66.

Abstract

To elucidate a widely suspected but inconclusive association between rs6280 in the dopamine receptor 3 gene (DRD3) and prevalence of tardive dyskinesia (TD), we conducted a meta-analysis of studies obtained in a systematic search of several bibliographic systems. We conducted several analyses of funnel plot asymmetry, overall heterogeneity, and study characteristics in analyses analogous to general, dominant and recessive inheritance models with the prevalence odds ratio (POR) as the measure of association. Thirteen eligible studies were identified with publication dates between 1997 and 2008. Evidence of funnel plot asymmetry was discerned in the dominant and general model analyses, but not in the recessive model analysis. Stratified analyses indicated that publication year, TD assessment method (Schooler–Kane criteria or other) and TD assessment frequency (single or repeated) were important study characteristics associated with heterogeneous PORs across studies. Studies conducted among patients with older age, fewer women or European (compared with Asian) ancestry reported stronger average PORs. Summary POR estimates under the dominant and general inheritance models were not warranted due to funnel plot asymmetry and heterogeneity. Under the recessive model, the summary estimate was POR = 0.93 (95% confidence interval: 0.70–1.23). We conclude that there is no or little association between DRD3 rs6280 polymorphisms and prevalence of TD. © 2009 Wiley-Liss, Inc.

Ancillary