How to Cite this Article: Sarginson JE, Lazzeroni LC, Ryan HS, Schatzberg AF, Murphy GMJr. 2009. FKBP5 Polymorphisms and Antidepressant Response in Geriatric Depression. Am J Med Genet Part B 153B:554–560.
FKBP5 polymorphisms and antidepressant response in geriatric depression†
Article first published online: 12 AUG 2009
Copyright © 2009 Wiley-Liss, Inc.
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Volume 153B, Issue 2, pages 554–560, March 2010
How to Cite
Sarginson, J. E., Lazzeroni, L. C., Ryan, H. S., Schatzberg, A. F. and Murphy, G. M. (2010), FKBP5 polymorphisms and antidepressant response in geriatric depression. Am. J. Med. Genet., 153B: 554–560. doi: 10.1002/ajmg.b.31019
- Issue published online: 18 FEB 2010
- Article first published online: 12 AUG 2009
- Manuscript Accepted: 29 JUN 2009
- Manuscript Received: 17 APR 2009
- National Institute of Mental Health
- The Department of Veterans Affairs
- Organon, Inc.
- antidepressive agents;
- FK506 binding protein 5
Genetic variation at the FKBP5 locus has been reported to affect clinical outcomes in patients treated with antidepressant medications in several studies. However, other reports have not confirmed this association. FKBP5 may regulate the sensitivity of the hypothalamic–pituitary–adrenal axis. We tested two FKBP5 single nucleotide polymorphisms (rs1360780 and rs3800373) in a sample of 246 geriatric patients treated for 8 weeks in a double-blind randomized comparison trial of paroxetine and mirtazapine. These two polymorphisms had previously been reported to predict efficacy in depressed patients treated with selective serotonin reuptake inhibitors such as paroxetine, and those treated with mirtazapine, an agent with both serotonergic and noradrenergic actions. However, we found no significant associations between these FKBP5 genetic variants and clinical outcomes. Neither mean Hamilton Depression Rating Scale scores nor time to remission or response were predicted by FKBP5 genetic variation. These results suggest that FKBP5 is unlikely to play a major role in determining antidepressant treatment outcomes in geriatric patients. © 2009 Wiley-Liss, Inc.