Research Article

Support of association between BRD1 and both schizophrenia and bipolar affective disorder†‡

  1. Mette Nyegaard1,2,
  2. Jacob E. Severinsen1,
  3. Thomas D. Als3,§,
  4. Anne Hedemand1,
  5. Steen Straarup3,
  6. Merete Nordentoft4,
  7. Andrew McQuillin5,
  8. Nicholas Bass5,
  9. Jacob Lawrence5,
  10. Srinivasa Thirumalai6,
  11. Ana C.P. Pereira5,
  12. Radhika Kandaswamy5,
  13. Gregory J. Lydall5,
  14. Pamela Sklar7,
  15. Edward Scolnick7,
  16. Shaun Purcell7,
  17. David Curtis8,
  18. Hugh M.D. Gurling5,
  19. Preben B. Mortensen9,
  20. Ole Mors3,
  21. Anders D. Børglum1,3,*

Article first published online: 19 AUG 2009

DOI: 10.1002/ajmg.b.31023

Issue

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

Volume 153B, Issue 2, pages 582–591, March 2010

Additional Information

How to Cite

Nyegaard, M., Severinsen, J. E., Als, T. D., Hedemand, A., Straarup, S., Nordentoft, M., McQuillin, A., Bass, N., Lawrence, J., Thirumalai, S., Pereira, A. C., Kandaswamy, R., Lydall, G. J., Sklar, P., Scolnick, E., Purcell, S., Curtis, D., Gurling, H. M., Mortensen, P. B., Mors, O. and Børglum, A. D. (2010), Support of association between BRD1 and both schizophrenia and bipolar affective disorder. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 153B: 582–591. doi: 10.1002/ajmg.b.31023

Author Information

  1. 1

    Institute of Human Genetics, University of Aarhus, Aarhus, Denmark

  2. 2

    Department of Haematology, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark

  3. 3

    Centre for Psychiatric Research, Aarhus University Hospital, Risskov, Denmark

  4. 4

    Department of Psychiatry, Bispebjerg Hospital, Copenhagen, Denmark

  5. 5

    Molecular Psychiatry Laboratory, Department of Mental Health Sciences, Windeyer Institute for Medical Science, Royal Free and University College Medical School, University College London, London, UK

  6. 6

    West Berkshire NHS Trust, Reading, UK

  7. 7

    Broad Institute (MIT/Harvard), Boston, Massachusetts

  8. 8

    Barts and the Royal London School of Medicine, Queen Mary College, London, UK

  9. 9

    National Centre for Register-Based Research, University of Aarhus, Aarhus, Denmark

  1. §

    Section for Population Genetics, National Institute of Aquatic Resources, Technical University of Denmark, Silkeborg, Denmark.

*Institute of Human Genetics, The Bartholin Building, Aarhus University, DK-8000 Aarhus C, Denmark.

  1. †

    Mette Nyegaard and Jacob E. Severinsen contributed equally to this work.

  2. ‡

    How to Cite this Article: Nyegaard M, Severinsen JE, Als TD, Hedemand A, Straarup S, Nordentoft M, McQuillin A, Bass N, Lawrence J, Thirumalai S, Pereira ACP, Kandaswamy R, Lydall GJ, Sklar P, Scolnick E, Purcell S, Curtis D, Gurling HMD, Mortensen PB, Mors O, Børglum AD. 2009. Support of Association Between BRD1 and Both Schizophrenia and Bipolar Affective Disorder. Am J Med Genet Part B 153B:582–591.

Publication History

  1. Issue published online: 18 FEB 2010
  2. Article first published online: 19 AUG 2009
  3. Manuscript Accepted: 14 JUL 2009
  4. Manuscript Received: 25 SEP 2008

Funded by

  • Danish Medical Research Council
  • Danish Strategic Research Council
  • Novo Nordisk Foundation
  • Villum Kann Rasmussen Foundation
  • Faculty of Health Sciences at Aarhus University
  • Desirée and Niels Ydes Foundation
  • Psychiatric Research Foundation

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article (HTML) Get PDF (220K)

Keywords:

  • 22q13;
  • association;
  • complex disorder;
  • neuronal development

Abstract

A recent study published by our group implicated the bromodomain containing protein 1 (BRD1) gene located at chromosome 22q13.33 with schizophrenia (SZ) and bipolar affective disorder (BPD) susceptibility and provided evidence suggesting a possible role for BRD1 in neurodevelopment. The present study reports an association analysis of BRD1 and the neighboring gene ZBED4 using a Caucasian case–control sample from Denmark and England (UK/DK sample: 490 patients with BPD, 527 patients with SZ, and 601 control individuals), and genotypes obtained from a BPD genome wide association (GWA) study of an overlapping English sample comprising 506 patients with BPD and 510 control individuals (UCL sample). In the UK/DK sample we genotyped 11 SNPs in the BRD1 region, of which six showed association with SZ (minimal single marker P-values of 0.0014), including two SNPs that previously showed association in a Scottish population [Severinsen et al. (2006); Mol Psychiatry 11(12): 1126–1138]. Haplotype analysis revealed specific risk as well as protective haplotypes with a minimal P-value of 0.0027. None of the 11 SNPs showed association with BPD. However, analyzing seven BRD1 SNPs obtained from the BPD GWA study, positive associations with BPD was observed with all markers (minimal P-value of 0.0014). The associations reported add further support for the implication of BRD1 with SZ and BPD susceptibility. © 2009 Wiley-Liss, Inc.

View Full Article (HTML) Get PDF (220K)