How to cite this article: Knight J, Rochberg NS, Saccone SF, Nurnberger JI, NIMH Genetics Initiative Bipolar Disorder Consortium, Rice JP. 2010. An Investigation of Candidate Regions for Association With Bipolar Disorder. Am J Med Genet Part B 153B:1292–1297.
An investigation of candidate regions for association with bipolar disorder†
Article first published online: 27 MAY 2010
Copyright © 2010 Wiley-Liss, Inc.
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Volume 153B, Issue 7, pages 1292–1297, October 2010
How to Cite
Knight, J., Rochberg, N. S., Saccone, S. F., Nurnberger, J. I. and Rice, J. P. (2010), An investigation of candidate regions for association with bipolar disorder. Am. J. Med. Genet., 153B: 1292–1297. doi: 10.1002/ajmg.b.31100
- Issue published online: 27 MAY 2010
- Article first published online: 27 MAY 2010
- Manuscript Accepted: 13 APR 2010
- Manuscript Received: 30 JUN 2009
- National Institute for Health Research (NIHR)
- NIH. Grant Numbers: 5R01MH059534-08, U24 MH068457
- National Institute of Mental Health
- bipolar disorder;
We performed a case–control study of 1,000 cases and 1,028 controls on 1,509 markers, 1,139 of which were located in a 8 Mb region on chromosome 6 (105–113 Mb). This region has shown evidence of involvement in bipolar disorder (BP) in a number of other studies. We find association between BP and two SNPs in the gene LACE1. SNP rs9486880 and rs11153113 (both have P-values of 2 × 10−5). Both P-values are in the top 5% of the distribution derived from null simulations (P = 0.02 and 0.01, respectively). LACE is a good candidate for BP; it is an ATPase. We genotyped 173 other markers in 17 other positional and/or functional loci but found no further evidence of association with BP. © 2010 Wiley-Liss, Inc.