How to Cite this Article: Chang X-L, Mao X-Y, Li H-H, Zhang J-H, Li N-N, Burgunder J-M, Peng R, Tan E-K. 2011. Association of GWAS Loci With PD in China. Am J Med Genet Part B 156:334–339.
Association of GWAS loci with PD in China†
Article first published online: 25 JAN 2011
Copyright © 2011 Wiley-Liss, Inc.
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Volume 156, Issue 3, pages 334–339, April 2011
How to Cite
Chang, X.-L., Mao, X.-Y., Li, H.-H., Zhang, J.-H., Li, N.-N., Burgunder, J.-M., Peng, R. and Tan, E.-K. (2011), Association of GWAS loci with PD in China. Am. J. Med. Genet., 156: 334–339. doi: 10.1002/ajmg.b.31167
- Issue published online: 11 MAR 2011
- Article first published online: 25 JAN 2011
- Manuscript Accepted: 6 DEC 2010
- Manuscript Received: 19 JUL 2010
- West China Hospital of Sichuan University and Duke–NUS Graduate Medical School
- Parkinson's disease;
Genome-wide association studies (GWAS) have identified numerous single-nucleotide polymorphisms (SNPs) at four loci (SNCA, PARK16, LRRK2, BST1) that can modulate the risk of Parkinson's disease (PD). The strength of these associations has yet to be clarified in Mainland China. Ethnic specific effect is an important consideration in GWAS analysis. Using a case–control methodology, we genotyped multiple SNPs at these four loci to investigate their association with risk of PD in Mainland China. A total of 1,146 study subjects comprising 636 patients with PD and 510 unrelated healthy controls were recruited. The minor alleles at SNPs rs894278, rs1994090, rs2046932, rs4698412, and rs7304279 were found to be significantly higher in cases than in controls, while the minor alleles were found to significantly reduce the risk of developing PD at SNPs rs823128, rs823156, rs6532194, rs1191532, and rs16856139. These associations remained after taking into considerations the effects of age and gender. We showed that multiple SNPs at LRRK2 and SNCA increase risk of PD, while PARK16 SNPs are associated with a lower risk of PD in China. Our study findings will contribute to further research using GWAS-linked data and research on ethnic specific effect of common variants. © 2011 Wiley-Liss, Inc.