Please Cite this Article: Liu S, Liu Y, Wang H, Zhou R, Zong J, Li C, Zhang X, Ma X. 2011. Association of Catechol-O-Methyl Transferase (COMT) Gene −287A/G Polymorphism With Susceptibility to Obsessive–Compulsive Disorder in Chinese Han Population. Am J Med Genet Part B 156:393–400.
Version of Record online: 22 FEB 2011
Copyright © 2011 Wiley-Liss, Inc.
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Volume 156, Issue 4, pages 393–400, June 2011
How to Cite
Liu, S., Liu, Y., Wang, H., Zhou, R., Zong, J., Li, C., Zhang, X. and Ma, X. (2011), Association of catechol-O-methyl transferase (COMT) gene −287A/G polymorphism with susceptibility to obsessive–compulsive disorder in Chinese Han population . Am. J. Med. Genet., 156: 393–400. doi: 10.1002/ajmg.b.31173
Shiguo Liu and Yanhui Liu contributed equally to this work.
- Issue online: 25 APR 2011
- Version of Record online: 22 FEB 2011
- Manuscript Accepted: 3 JAN 2011
- Manuscript Received: 29 JUL 2010
- National Basic Research Program of China. Grant Number: 2007CB511905
- National Infrastructure Program of Chinese Genetic Resources. Grant Number: 2006DKA21300
- National Natural Science Foundation of China. Grant Number: 30470953
- COMT −287A/G polymorphism;
- principal component analysis;
- genotype and phenotype
Several studies suggested a genetic component in the etiology of obsessive–compulsive disorder (OCD). COMT involves in the degradation of dopamine and norepinephrin. As another functional SNP locus, COMT −287A/G polymorphism showed an effect on enzyme activity, suggesting that it may influence brain dopamine levels. To identify association of COMT −287A/G polymorphism with susceptibility to OCD in Chinese Han population. We evaluate the genetic contribution of the COMT −287A/G polymorphism in 200 OCD patients and 403 OCD-free control of Chinese Han population by PCR-RFLP. In addition, we investigate whether COMT −287A/G polymorphism is associated with one or more of these symptom dimensions or other characteristics such as sex, age of onset, and tic-relatedness and evaluate the association of the factorial structure of OCD symptoms from the Y-BOCS checklist with the COMT −287A/G polymorphism. A statistical difference was found in the genotypic frequencies of COMT −287A/G between the OCD and control groups (χ2 = 13.99, DF = 2, P = 0.00091) and in the genotypic frequencies of GG genotype versus AA and AG genotypes of COMT −287 (χ2 = 13.49, DF = 1, P = 0.00024, OR = 3.43, 95% CI = 1.78–6.62). There was a trend for an association in the genotypic distributions of COMT −287A/G polymorphism of males (χ2 = 27.81; DF = 2; P < 0.001) and females (χ2 = 7.31; DF = 2; P = 0.026) between the OCD patients and the controls. Using principal component analysis, we derived 5 factors from 12 main contents of OCD symptoms from the Y-BOCS checklist and found no association with COMT −287A/G polymorphism. Our study supports the involvement of the COMT −287A/G polymorphism in the genetic susceptibility to OCD in Chinese Han population. © 2011 Wiley-Liss, Inc.