Rhodri Ll Smith, Deborah Knight are joint first authors
Analysis of neurogranin (NRGN) in schizophrenia†
Article first published online: 2 MAY 2011
Copyright © 2011 Wiley-Liss, Inc.
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Volume 156, Issue 5, pages 532–535, July 2011
How to Cite
Smith, R. Ll., Knight, D., Williams, H., Dwyer, S., Richards, A., Kirov, G., O'Donovan, M. C. and Owen, M. J. (2011), Analysis of neurogranin (NRGN) in schizophrenia. Am. J. Med. Genet., 156: 532–535. doi: 10.1002/ajmg.b.31191
Please Cite this Article: Smith RLl, Knight D, Williams H, Dwyer S, Richards A, Kirov G, O'Donovan MC, Owen MJ. 2011. Analysis of Neurogranin (NRGN) in Schizophrenia. Am J Med Genet Part B 156:532–535.
- Issue published online: 10 JUN 2011
- Article first published online: 2 MAY 2011
- Manuscript Accepted: 11 MAR 2011
- Manuscript Received: 22 DEC 2010
- Medical Research Council
A recent study reported a genome-wide significant association between schizophrenia and rs12807809—a SNP located approximately 3 kbp upstream of the neurogranin gene (NRGN). We sought to determine if (a) NRGN contains common exonic variants or variants affecting expression (eQTLs) that could account for the association with rs12807809 and (b) there exist rare non-synonymous highly penetrant variants that could potentially confer high risk of schizophrenia. We sequenced all four exons of NRGN in a screening set of 14 individuals but found no novel common polymorphisms. We additionally sequenced the coding exons in up to 1,113 individuals (699 cases) but this revealed only a singleton-coding variant in exon 2 (G246T leading to Gly-55 Val amino acid change) in which prediction of function analysis suggested is likely to be benign. Finally, analysis of a brain expression dataset of at least 130 individuals did not identify any eQTLs that were correlated with associated SNP rs12807809 following correction for multiple testing. © 2011 Wiley-Liss, Inc.