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Analysis of neurogranin (NRGN) in schizophrenia

Authors

  • Rhodri Ll. Smith,

    Corresponding author
    1. MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine, Henry Wellcome Building, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom
    • MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine, Henry Wellcome Building, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom.
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    • Rhodri Ll Smith, Deborah Knight are joint first authors

  • Deborah Knight,

    1. MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine, Henry Wellcome Building, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom
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    • Rhodri Ll Smith, Deborah Knight are joint first authors

  • Hywel Williams,

    1. MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine, Henry Wellcome Building, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom
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  • Sarah Dwyer,

    1. MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine, Henry Wellcome Building, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom
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  • Alex Richards,

    1. MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine, Henry Wellcome Building, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom
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  • George Kirov,

    1. MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine, Henry Wellcome Building, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom
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  • Michael C. O'Donovan,

    1. MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine, Henry Wellcome Building, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom
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  • Michael J. Owen

    1. MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine, Henry Wellcome Building, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom
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  • Please Cite this Article: Smith RLl, Knight D, Williams H, Dwyer S, Richards A, Kirov G, O'Donovan MC, Owen MJ. 2011. Analysis of Neurogranin (NRGN) in Schizophrenia. Am J Med Genet Part B 156:532–535.

Abstract

A recent study reported a genome-wide significant association between schizophrenia and rs12807809—a SNP located approximately 3 kbp upstream of the neurogranin gene (NRGN). We sought to determine if (a) NRGN contains common exonic variants or variants affecting expression (eQTLs) that could account for the association with rs12807809 and (b) there exist rare non-synonymous highly penetrant variants that could potentially confer high risk of schizophrenia. We sequenced all four exons of NRGN in a screening set of 14 individuals but found no novel common polymorphisms. We additionally sequenced the coding exons in up to 1,113 individuals (699 cases) but this revealed only a singleton-coding variant in exon 2 (G246T leading to Gly-55 → Val amino acid change) in which prediction of function analysis suggested is likely to be benign. Finally, analysis of a brain expression dataset of at least 130 individuals did not identify any eQTLs that were correlated with associated SNP rs12807809 following correction for multiple testing. © 2011 Wiley-Liss, Inc.

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