How to cite this article as follows: O'Rourke JA, Scharf J, Platko J, Stewart SE, Illmann C, Geller DA, King RA, Leckman JF, Pauls DL. 2011. The Familial Association of Tourette's Disorder and ADHD: The Impact of OCD Symptoms. Am J Med Genet Part B 156:553–560.
The familial association of tourette's disorder and ADHD: The impact of OCD symptoms†
Version of Record online: 6 MAY 2011
Copyright © 2011 Wiley-Liss, Inc.
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Volume 156, Issue 5, pages 553–560, July 2011
How to Cite
O'Rourke, J. A., Scharf, J. M., Platko, J., Stewart, S. E., Illmann, C., Geller, D. A., King, R. A., Leckman, J. F. and Pauls, D. L. (2011), The familial association of tourette's disorder and ADHD: The impact of OCD symptoms. Am. J. Med. Genet., 156: 553–560. doi: 10.1002/ajmg.b.31195
- Issue online: 10 JUN 2011
- Version of Record online: 6 MAY 2011
- Manuscript Accepted: 6 APR 2011
- Manuscript Received: 29 MAR 2011
- NINDS. Grant Numbers: NS-16648, MH-49351, MH076273
- McIngvale Foundation
- Tourette's disorder;
Tourette's disorder (TD) frequently co-occurs with attention-deficit/hyperactivity disorder (ADHD) and obsessive compulsive disorder (OCD). While the relationship between TD and OCD suggests that they share etiological factors, the exact relationship between TD and ADHD is less clear. The goal of the current analyses was to understand better the familial relationship between DSM-IV ADHD and TD. Direct interview diagnostic data from a case–control study of 692 relatives of 75 comorbid TD and ADHD (TD + ADHD), 74 TD without ADHD (TD Only), 41 ADHD without TD (ADHD Only), and 49 control probands were analyzed. Hierarchical loglinear modeling was used to explore association patterns between TD, ADHD, and OCD or sub-clinical OCD (OCD/OCDsub) diagnoses among the 190 affected probands and their 538 relatives. The presence of OCD or OCDsub diagnosis in a proband was associated with a significantly increased risk of comorbid TD + ADHD in his/her relatives. The finding of an association between TD, ADHD and a proband OCD/OCDsub diagnosis was unexpected. The current results suggest that TD, ADHD, and OCD symptoms have overlapping neurobiology when occurring in families of TD and/or ADHD probands. © 2011 Wiley-Liss, Inc.