How to Cite this Article: Schosser A, Gaysina D, Cohen-Woods S, Domenici E, Perry J, Tozzi F, Korszun A, Gunasinghe C, Gray J, Jones L, Binder EB, Holsboer F, Craddock N, Owen MJ, Craig IW, Farmer AE, Muglia P, McGuffin P. 2011. A Follow-Up Case–Control Association Study of Tractable (Druggable) Genes in Recurrent Major Depression. Am J Med Genet Part B 156:640–650.
A follow-up case–control association study of tractable (druggable) genes in recurrent major depression†
Article first published online: 31 MAY 2011
Copyright © 2011 Wiley-Liss, Inc.
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Volume 156, Issue 6, pages 640–650, September 2011
How to Cite
Schosser, A., Gaysina, D., Cohen-Woods, S., Domenici, E., Perry, J., Tozzi, F., Korszun, A., Gunasinghe, C., Gray, J., Jones, L., Binder, E.B., Holsboer, F., Craddock, N., Owen, M.J., Craig, I.W., Farmer, A.E., Muglia, P. and McGuffin, P. (2011), A follow-up case–control association study of tractable (druggable) genes in recurrent major depression. Am. J. Med. Genet., 156: 640–650. doi: 10.1002/ajmg.b.31204
- Issue published online: 10 AUG 2011
- Article first published online: 31 MAY 2011
- Manuscript Accepted: 25 APR 2011
- Manuscript Received: 12 MAY 2010
- candidate genes;
- case–control study
The High-Throughput Disease-specific target Identification Program (HiTDIP) aimed to study case–control association samples for 18 common diseases. Here we present the results of a follow-up case–control association study of HiTDIP in major depressive disorder (MDD). The HiTDIP in MDD was conducted in a sample of 974 cases of recurrent MDD of white German origin collected at the Max-Planck Institute (MP-GSK) and 968 ethnically matched controls screened for lifetime absence of depression. Six genes were identified as of interest for a follow-up, based on the strength of the association and based on the interest as potential candidate target for developing new treatment for depression: Solute Carrier Family 4 Member 10 (SLC4A10), Dipeptidyl Peptidase IV (DPP4), Dopamine Receptor D3 (DRD3), Zinc Finger Protein 80 (ZNF80), Nitric Oxide Synthase 2A (NOS2A) and Peroxisome Proliferator-Activated Receptor-Gamma, Coactivator 1, Alpha (PPARGC1A). Within the current study, we attempted to follow-up these findings in a sample from the UK, the Depression Case Control (DeCC) sample consisting of 1,196 cases and 842 screened controls, phenotyped using exactly the same methods as the MP-GSK sample. Performing Cochran–Mantel–Haenzel statistics to test for genotypic and/or allelic differences between the DeCC and MP-GSK samples, we found no significant differences, thus being able to combine the two samples for association testing. In the combined sample of 2,170 MDD cases and 1,810 controls, there were positive findings in the Nitric Oxide Synthase 2A (NOS2A) gene both using single SNP analysis and haplotype analysis. © 2011 Wiley-Liss, Inc.