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Association analysis of ANK3 gene variants in nordic bipolar disorder and schizophrenia case–control samples

Authors

  • Martin Tesli,

    Corresponding author
    1. Institute of Clinical Medicine, University of Oslo, Oslo, Norway
    2. Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway
    • Oslo University Hospital HF, Division of Mental Health and Addiction Psychosis Research Unit/TOP, Kirkeveien 166, N-0407 Oslo, Norway
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  • Pernille Koefoed,

    1. Department of Neuroscience and Pharmacology, Laboratory of Neuropsychiatry, University of Copenhagen, Copenhagen, Denmark
    2. Psychiatric Centre Copenhagen, Department O, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
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  • Lavinia Athanasiu,

    1. Institute of Clinical Medicine, University of Oslo, Oslo, Norway
    2. Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway
    3. Department of Medical Genetics, Oslo University Hospital, Oslo, Norway
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  • Morten Mattingsdal,

    1. Department of Medical Genetics, Oslo University Hospital, Oslo, Norway
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  • Omar Gustafsson,

    1. Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway
    2. deCODE Genetics, Reykjavik, Iceland
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  • Ingrid Agartz,

    1. Institute of Clinical Medicine, University of Oslo, Oslo, Norway
    2. Department of Clinical Neuroscience, HUBIN Project, Psychiatry Section, Karolinska Institutet and Hospital, Stockholm, Sweden
    3. Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway
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  • Lars M. Rimol,

    1. Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway
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  • Andrew Brown,

    1. Institute of Clinical Medicine, University of Oslo, Oslo, Norway
    2. Department of Biostatistics, University of Oslo, Oslo, Norway
    3. Department of Mathematics, University of Oslo, Oslo, Norway
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  • Katrine V. Wirgenes,

    1. Institute of Clinical Medicine, University of Oslo, Oslo, Norway
    2. Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway
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  • Lisa-Lena Smorr,

    1. Institute of Clinical Medicine, University of Oslo, Oslo, Norway
    2. Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway
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  • Anna K. Kähler,

    1. Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway
    2. Department of Genetics, University of North Carolina at Chapel Hill, North Carolina 27599
    3. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
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  • Thomas Werge,

    1. Research Institute of Biological Psychiatry, Mental Health Center Sct. Hans, Copenhagen University Hospital, Roskilde, Denmark
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  • Ole Mors,

    1. Center for Psychiatric Research, Aarhus University Hospital, Aarhus, Denmark
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  • Erling Mellerup,

    1. Department of Neuroscience and Pharmacology, Laboratory of Neuropsychiatry, University of Copenhagen, Copenhagen, Denmark
    2. Psychiatric Centre Copenhagen, Department O, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
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  • Erik G. Jönsson,

    1. Department of Clinical Neuroscience, HUBIN Project, Psychiatry Section, Karolinska Institutet and Hospital, Stockholm, Sweden
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  • Ingrid Melle,

    1. Institute of Clinical Medicine, University of Oslo, Oslo, Norway
    2. Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway
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  • Gunnar Morken,

    1. Østmarka Psychiatric Department, St. Olavs Hospital, Trondheim, Norway
    2. Institute of Neuroscience, Norwegian University of Technology and Science, Trondheim, Norway
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  • Srdjan Djurovic,

    1. Institute of Clinical Medicine, University of Oslo, Oslo, Norway
    2. Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway
    3. Department of Medical Genetics, Oslo University Hospital, Oslo, Norway
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  • Ole A. Andreassen

    1. Institute of Clinical Medicine, University of Oslo, Oslo, Norway
    2. Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway
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  • How to Cite this Article: Tesli M, Koefoed P, Athanasiu L, Mattingsdal M, Gustafsson O, Agartz I, Rimol LM, Brown A, Wirgenes KV, Smorr L-L, Kähler AK, Werge T, Mors O, Mellerup E, Jönsson EG, Melle I, Morken G, Djurovic S, Andreassen OA. 2011. Association Analysis of ANK3 Gene Variants in Nordic Bipolar Disorder and Schizophrenia Case–Control Samples. Am J Med Genet Part B 156:969–974.

Abstract

Genetic variants in ankyrin 3 (ANK3) have recently been shown to be associated with bipolar disorder (BD). We genotyped three ANK3 SNPs previously found to be associated with BD (rs10994336, rs1938526, and rs9804190) in a Scandinavian BD case–control sample (N = 854/2,614). Due to evidence of genetic overlap between BD and schizophrenia (SZ), we also genotyped these three SNPs in a Scandinavian SZ case–control sample (N = 1,073/2,919). Combining our Scandinavian samples with an Icelandic sample (N = 435 BD cases, 651 SZ cases, and 11,491 healthy controls), we found rs10994336 and rs9804190 to be nominally significantly associated with BD in this combined Nordic BD sample (N = 1,289/14,105). Nominal P was 0.015/0.018 (fixed/random effect) for rs10994336 (Bonferroni corrected P = 0.044/0.053) and 0.023 for rs9804190 (Bonferroni corrected P = 0.069). None of the SNPs were significantly associated with SZ in the combined Nordic SZ case–control sample (N = 1,724/14,410). These results further support that ANK3 is a susceptibility gene specific to BD and that more than one risk locus is involved. © 2011 Wiley Periodicals, Inc.

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